Anti-IRAK1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Supplier: Bioss
BS-3193R-A350
BOSSBS-3193R-A350EA 921 EUR
BOSSBS-3193R-A350
Anti-IRAK1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antibodies
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds toMore Product Information
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