You Searched For: 2-Naphthylacetic acid

Catalog Number: (APOSBITC2004-1MG)

Supplier: Apollo Scientific

Description: Human recombinant ENA-78

UOM: 1 * 1 mg

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Catalog Number: (APOSBITC2030-1MG)

Supplier: Apollo Scientific

Description: Human recombinant MCP-4

UOM: 1 * 1 mg

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Catalog Number: (APOSBITC2046-1MG)

Supplier: Apollo Scientific

Description: Human recombinant SDF-1b

UOM: 1 * 1 mg

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Catalog Number: (APOSBITC2007-1MG)

Supplier: Apollo Scientific

Description: Human recombinant IL-8-77

UOM: 1 * 1 mg

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Catalog Number: (APOSBITC2017-1MG)

Supplier: Apollo Scientific

Description: Human recombinant I-309

UOM: 1 * 1 mg

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Supplier: SELENOZYME

Description: The human GPX2 selenoprotein is encoded by the GPX2 gene and has potent hydrogen peroxide reducing activity using glutathione.
We provide the human GPX2 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 0,5 to 5 units.

Supplier: SELENOZYME

Description: The human TrxR2 selenoprotein is encoded by the TXNRD2 gene and exerts a wide range of functions in mitochondrial redox control and antioxidant systems. We provide the main mitochondrial isoform of the human TrxR2 enzyme with more than 90% Sec contents and more than 95% purity in aliquots at amounts from 5 to 50 units.

Supplier: SELENOZYME

Description: The human GPX1 selenoprotein is encoded by the GPX1 gene and has potent hydrogen peroxide reducing activity using glutathione.
We provide the human GPX1 enzyme with approx. 20% Sec contents, mixed with inactive forms containing Sec-to-Lys and Sec-to-Gln substitutions, at more than 95% purity in aliquots at amounts from 0,5 to 5 units.

Catalog Number: (CAYM10006217-25)

Supplier: Cayman Chemical

Description: Renin is an aspartyl protease of approximately 40 kDa produced in the kidney by juxtaglomerular cells of the macula densa.

UOM: 1 * 25 µG

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Catalog Number: (PRSI91-089)

Supplier: ProSci Inc.

Description: BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.

UOM: 1 * 0,05 mg

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Catalog Number: (PRSI92-051)

Supplier: ProSci Inc.

Description: DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.

UOM: 1 * 0,05 mg

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Catalog Number: (PRSI96-693)

Supplier: ProSci Inc.

Description: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

UOM: 1 * 0,1 mg

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Catalog Number: (PRSI96-215)

Supplier: ProSci Inc.

Description: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

UOM: 1 * 0,2 mg

New Product Sale

Catalog Number: (PRSI91-603)

Supplier: ProSci Inc.

Description: Angiopoietin-related protein 4（ANGPTL4）is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

UOM: 1 * 0,05 mg

New Product Sale

Catalog Number: (PRSI92-109)

Supplier: ProSci Inc.

Description: Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.

UOM: 1 * 0,05 mg

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Catalog Number: (786-048)

Supplier: G-Biosciences

Description: Chymostatin inhibits serine proteases having a chymotrypsin-like specificity, including α, β γ, and δ chymotrypsin, and most cysteine proteases including cathepsins B, H, L. Soluble in DMSO.

UOM: 1 * 5 mg

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