Anti-TYMS Mouse Monoclonal Antibody (CF640R) [clone: TS106 TMS715]

Supplier: Biotium
BNC400716-500 BNC400716-100
BNC400716-500EA 560 EUR
BNC400716-500 BNC400716-100
Anti-TYMS Mouse Monoclonal Antibody (CF640R) [clone: TS106 TMS715]
Antibodies
This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. ExpressionMore Product Information
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SPECIFICATIONS

Antigen symbol TYMS
Environmentally Preferable
Antigen name Thymidylate Synthase
Antigen synonyms TSase|TS|TMS|Tyms thymidylate synthetase|dTMP synthase|TYMS protein
Antibody type Primary
Clonality Monoclonal
Conjugation CF® 640R
Clone Clone TS106 TMS715
Reactivity Human
Host Mouse
Gene ID 369762
Isotype IgGs
ImmunoChemistry Yes
ImmunoFluorescence Yes
Concentration 0,1 mg/ml
Storage buffer PBS/0,1% BSA/0,05% azide

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