You Searched For: 3-Chloro-2-methylphenylboronic acid

Description: Anti-MAP2K1 Rabbit Polyclonal Antibody

Catalog Number: USBIM2865-04A1

UOM: 1 * 100 µG

Supplier: US Biological

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Description: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

Catalog Number: BOSSBS-6239R-A647

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-MTTP Rabbit Polyclonal Antibody (Biotin)

Catalog Number: USBI038686-BIOTIN

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-Proline Dehydrogenase Rabbit Polyclonal Antibody

Catalog Number: USBIP9010-65A

UOM: 1 * 200 µl

Supplier: US Biological

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Description: TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

Catalog Number: BOSSBS-2457R-A647

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-AP1M1 Rabbit Polyclonal Antibody (APC (Allophycocyanin))

Catalog Number: USBI031937-APC

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-AKT1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: USBIA1125-11B-HRP

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-LYPLA1 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Catalog Number: USBI038028-PE

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-LRMP Rabbit Polyclonal Antibody (APC (Allophycocyanin))

Catalog Number: USBI037932-APC

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-Stat 4 Rabbit Polyclonal Antibody (FITC (Fluorescein))

Catalog Number: USBIS7972-02F-FITC

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-TSC1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: USBI043331-HRP

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Catalog Number: BOSSBS-1736R-A488

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Anti-DIAPH3 Rabbit Polyclonal Antibody

Catalog Number: USBI034641

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-IGHG4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: USBI036919-HRP

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-PGA3 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: USBI039907-FITC

UOM: 1 * 200 µl

Supplier: US Biological

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Description: Anti-KRT5 Mouse Monoclonal Antibody [clone: 13B213]

Catalog Number: USBI030135

UOM: 1 * 100 µl

Supplier: US Biological

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