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Catalog Number: (BOSSBS-8618R-A647)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8618R-A350)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


Supplier: VWR Collection
Description: The HAVER rotating sample reducer produces small but representative sample quantities of solids and suspensions. It combines three dividing methods in one unit and achieves an accuracy of 99,9%.

Catalog Number: (MFLX73805-00)
Supplier: Avantor Fluid Handling
Description: Easily meansure flow of your Feed Verification Diaphragm Pump.
UOM: 1 * 1 items


Catalog Number: (BOSSBS-15013R-A680)
Supplier: Bioss
Description: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11514R-A350)
Supplier: Bioss
Description: The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-12145R-CY3)
Supplier: Bioss
Description: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-12145R-A488)
Supplier: Bioss
Description: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-12145R-HRP)
Supplier: Bioss
Description: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-12145R-A350)
Supplier: Bioss
Description: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8618R-CY5)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-1095R-A647)
Supplier: Bioss
Description: The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-5918R-A555)
Supplier: Bioss
Description: Angiopoietin-like protein 3 (Angptl3) functions as a potent lipoprotein lipase inhibitor and is an important component of plasma triglyceride homeostasis. Angptl3 also plays a role in adipose formation and angiogenesis through its interaction with integrin ?v)beta(3). It is secreted by the liver and is functionally defined by the C-terminal fibrinogen (FBN)-like domain and an N-terminal coiled-coil domain. Angptl3 regulates circulating triglyceride levels during different nutritional states thereby mediating the feeding/fasting cycle. A deficiency of Angptl3 results in abnormally low lipid levels, and a repression of the protein may be protective against atherosclerosis. Angptl3 may also play an important role in hyperlipidemia in diabetes.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8618R-A750)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterised as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8618R-FITC)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8618R-HRP)
Supplier: Bioss
Description: The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
UOM: 1 * 100 µl


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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