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Image Unavailable-BOSSBS-2936R-A350

Anti-ARHGEF7 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Description: ARHGEF7 is a p21-activated protein kinase (Pak)-interacting exchange factor that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. It is expressed ubiquitously in all the tissue examined and other isoforms are expressed mainly in the central nervous system. Regulated phosphorylation of ARHGEF7 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation.Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.
Catalog Number: BOSSBS-2936R-A350
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-MFLX32457-16

Masterflex® Direct-Read Variable-Area Flowmeters, Air and Water, Acrylic Housing, Avantor®

Description: Durable single-piece body withstands severe shock and vibration.
Catalog Number: MFLX32457-16
UOM: 1 * 1 items
Supplier: Avantor Fluid Handling
Product Image-SARBYCS31-652-AC00

Calibration weight sets, class E2, Proof Line

Description: These class E2 weight sets include aluminium (1 to 5 mg) or nickel silver (10 to 500 mg) or stainless steel (1 g and higher) weights.
Catalog Number: SARBYCS31-652-AC00
UOM: 1 * 1 items
Supplier: Sartorius Balances
Product Image-MILFS2GVU02RE

Stericup® Quick Release-GV Sterile Vacuum Filtration Systems

Description: The Stericup® vacuum filtration system is the most efficient single-use, disposable process for sterile media preparation. It combines a Steritop® filter unit with a receiver flask for processing and storing volumes from 150 to 1000 ml in a single, ready-to-use format. Its no-tip, easy-grip flask design and balanced profile improve stability during filtration in tight laminar flow hoods, and the convenient labeling and packaging make it easy to open and track each device.
Catalog Number: MILFS2GVU02RE
UOM: 1 * 12 items
Supplier: Merck
Image Unavailable-BOSSBS-4114R-CY5

Anti-IKBKE Rabbit Polyclonal Antibody (Cy5®)

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
Catalog Number: BOSSBS-4114R-CY5
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-4114R-A647

Anti-IKBKE Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Description: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
Catalog Number: BOSSBS-4114R-A647
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-MFLX32051-18

Masterflex® Direct Reading Variable Area Flowmeters for Water, PFA Housing, Avantor®

Description: A unique combination of rugged frame and chemically inert wetted materials.
Catalog Number: MFLX32051-18
UOM: 1 * 1 items
Supplier: Avantor Fluid Handling
Product Image-21-020-CV

Hank's balanced salt solutions (HBSS), Corning®

Description: Hanks' Balanced Salt Solution (HBSS) is a buffer used to maintain a physiological pH for cells maintained in non-CO₂ atmospheric conditions.
Catalog Number: 21-020-CV
UOM: 1 * 6 items
Supplier: Corning

Certificates


Image Unavailable-BOSSBS-12274R-A488

Anti-OVOL2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Description: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental signaling pathways such as Wnt and TGF-∫/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.
Catalog Number: BOSSBS-12274R-A488
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-11830R-HRP

Anti-CA10 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Description: Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA X also referred to as Carbonic anhydrase-related protein X (CA-RP X) or Cerebral protein 15, is a member of the carbonic anhydrase family that lacks two of the three Zn-binding motifs essential for carbonic anhydrase activity. For this reason, CA X does not exhibit catalytic activity. It is expressed primarily in brain and kidney and may play a role in brain development.
Catalog Number: BOSSBS-11830R-HRP
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-12274R-FITC

Anti-OVOL2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental signaling pathways such as Wnt and TGF-∫/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.
Catalog Number: BOSSBS-12274R-FITC
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-JMBVAFHMINIMMSHB02

Accessories for Avantor® Small Scale Magnetic Mixing Systems

Description: Accessories for Avantor® Small Scale Magnetic Mixing Systems
Catalog Number: JMBVAFHMINIMMSHB02
UOM: 1 * 1 items
Supplier: JM SEPARATIONS

New Product


Image Unavailable-BOSSBS-11677R-HRP

Anti-UCHL1+3 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Description: The two ubiquitin C-terminal hydrolase (UCH) enzymes, UCHL1 and UCHL3, deubiquitinate ubiquitin-protein conjugates and control the cellular balance of ubiquitin. UCHL1 and UCHL3 are both small proteins of ~220 amino acids that share more than 40% amino acid sequence identity. UCHL3 is universally expressed in all tissues, while UCHL1 is expressed exclusively in neuronal tissue, testis and ovary. The activity of UCHL3 is more than 200 fold higher than UCHL1 when a fluorogenic ubiquitin substrate is used. UCHL1 associates with monoubiquitin and UCHL3 binds to Nedd8, ubiquitin-like protein. UCHL1 and UCHL3 play a role in the regulation of neuronal development and spermatogenesis. UCHL1 is involved in the pathogenesis of Parkinson’s disease (PD) and Alzheimer’s disease (AD).
Catalog Number: BOSSBS-11677R-HRP
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-2988R-CY5

Anti-MFN2 Rabbit Polyclonal Antibody (Cy5®)

Description: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Catalog Number: BOSSBS-2988R-CY5
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-2912R-CY5

Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (Cy5®)

Description: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
Catalog Number: BOSSBS-2912R-CY5
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-MFLX32461-26

Masterflex® Direct-Read Variable-Area Flowmeters with Valve, English Units, Avantor®

Description: Meter with valve provides flow control through a highly durable meter body.
Catalog Number: MFLX32461-26
UOM: 1 * 1 items
Supplier: Avantor Fluid Handling
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