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Image Unavailable-BOSSBS-4000R-A680

Anti-CHK2 ser19 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-4000R-A680)
Supplier: Bioss
Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5275R-A647

Anti-CHEK2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-5275R-A647)
Supplier: Bioss
Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5275R-A750

Anti-CHK2 Thr387 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-5275R-A750)
Supplier: Bioss
Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
UOM: 1 * 100 µl
Image Unavailable-SIALS153-25MG

SQ 22,536 ADENYLATE CYCLASE INH 1 * 25 mg

Catalog Number: (SIALS153-25MG)
Supplier: Merck
Description: SQ 22,536 ADENYLATE CYCLASE INH 1 * 25 mg
UOM: 1 * 25 mg
Image Unavailable-CAYM13339-50

SQ 22,536 (50 mg) 1 * 50 mg

Catalog Number: (CAYM13339-50)
Supplier: Cayman Chemical
Description: SQ 22,536 (50 mg) 1 * 50 mg
UOM: 1 * 50 mg
Image Unavailable-CAYM13339-25

SQ 22,536 (25 mg) 1 * 25 mg

Catalog Number: (CAYM13339-25)
Supplier: Cayman Chemical
Description: SQ 22,536 (25 mg) 1 * 25 mg
UOM: 1 * 25 mg
Product Image-ENTEH201003262C02

TRAY - CHIP SQ PKTS H20-100-32-62C02 Material: STAT-PRO 150 (Black Conductive Polypropylene) Pocket Dimensions: 2.54mm x 2.54mm x 0.81mm Capacity: 10x10 (100) 1 * 100 ST

Catalog Number: (ENTEH201003262C02)
Supplier: ENTEGRIS
Description: TRAY - CHIP SQ PKTS H20-100-32-62C02 Material: STAT-PRO 150 (Black Conductive Polypropylene) Pocket Dimensions: 2.54mm x 2.54mm x 0.81mm Capacity: 10x10 (100) 1 * 100 ST
UOM: 1 * 100 items
Image Unavailable-MILLSQPAKACARE

The SQPAK Care A Cleaner prevents scaling in the Milli-Q SQ 2Series production station. The purification technology of the SQPAK Care A - Acid Cleaner includes an acidic reagent to remove mineral scaling in hydraulic parts null

Catalog Number: (MILLSQPAKACARE)
Supplier: Merck
Description: The SQPAK Care A Cleaner prevents scaling in the Milli-Q SQ 2Series production station. The purification technology of the SQPAK Care A - Acid Cleaner includes an acidic reagent to remove mineral scaling in hydraulic parts null
UOM:

New Product


Image Unavailable-APOSOR46244-25G

2-Chloro-5-methylpyrimidine 98%

Supplier: Apollo Scientific
Description: 2-Chloro-5-methylpyrimidine 98%

Product Image-ACRO454040010

2,5-Dichloropyrimidine 95%

Catalog Number: (ACRO454040010)
Supplier: Thermo Fisher Scientific
Description: 2,5-Dichloropyrimidine 95%
UOM: 1 * 1 g

MSDS


Product Image-ACRO426820010

2-Chloro-4-methoxypyrimidine 98%

Supplier: Thermo Fisher Scientific
Description: 2-Chloro-4-methoxypyrimidine 98%

MSDS

Image Unavailable-APOSOR46001-100G

2-Chloro-4-methoxypyrimidine

Catalog Number: (APOSOR46001-100G)
Supplier: Apollo Scientific
Description: 2-Chloro-4-methoxypyrimidine
UOM: 1 * 100 g
Image Unavailable-APOSOR30544-500MG

2-Chloropyrimidine-4-carboxamide

Catalog Number: (APOSOR30544-500MG)
Supplier: Apollo Scientific
Description: 2-Chloropyrimidine-4-carboxamide
UOM: 1 * 500 mg
Image Unavailable-APOSOR938765-250MG

2-Chloro-5-phenylpyrimidine 95%

Supplier: Apollo Scientific
Description: 2-Chloro-5-phenylpyrimidine 95%

Image Unavailable-H64773.14

2-Chloro-5-methylpyrimidine 97%

Supplier: Thermo Fisher Scientific
Description: 2-Chloro-5-methylpyrimidine 97%

Certificates

Image Unavailable-APOSOR17514-25G

2,5-Dichloropyrimidine 97+%

Supplier: Apollo Scientific
Description: 2,5-Dichloropyrimidine 97+%

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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