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Image Unavailable-BNUM0894-50

Anti-PNL2 Mouse Monoclonal Antibody [clone: PNL2]

Catalog Number: (BNUM0894-50)
Supplier: Biotium
Description: Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF.
UOM: 1 * 50 µl
Product Image-STMC07469

DNase I

Supplier: STEMCELL Technologies
Description: For digestion of DNA.

Product Image-STMC07419

Collagenase Type II

Supplier: STEMCELL Technologies
Description: For digestion of native collagen fibrils.

Product Image-STMC07442

Collagenase C, ACF

Supplier: STEMCELL Technologies
Description: Animal component-free collagenase for the digestion of native collagen fibrils.

Product Image-STMC07423

Collagenase Type III

Supplier: STEMCELL Technologies
Description: For digestion of native collagen fibrils.

Product Image-PIER87779

Pierce™ Detergent Removal Spin Columns and Resin

Supplier: Thermo Fisher Scientific
Description: Pierce™ Detergent removal resin enables removal of commonly used ionic, non-ionic and zwitterionic detergents from protein/peptide digest solutions.

Product Image-STMC07427

Collagenase Type IV

Supplier: STEMCELL Technologies
Description: For digestion of native collagen fibrils.

Image Unavailable-BNUM1218-50

Anti-CELA3B Mouse Monoclonal Antibody (Purified, BSA-free) [clone: CELA3B/1218]

Catalog Number: (BNUM1218-50)
Supplier: Biotium
Description: This MAb recognizes a protein of ~17 kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
UOM: 1 * 50 µl
Image Unavailable-AC116

Proteinase K and OB protease

Supplier: OMEGA BIO-TEK
Description: For enzyme digestion during DNA and RNA preparation. Both OB Protease and Proteinase K offer broad substrate specificity with high activity for a wide range of salts, denaturant and detergent, pH, and temperature conditions. Proteinase K is a subtilisin-type protease isolated from the saprophytic fungus <i>Tritirachiumalbum</i> and is particularly suitable for short digestion times. It possesses a high specific activity which remains stable over a wide range of temperatures and pH values with substantially increased activity at higher temperature.

MSDS Certificates

Image Unavailable-SIALG5009-100G

Bovine gamma-globulin (from Blood)

Supplier: Merck
Description: γ-Globulin from bovine blood are categorised by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. It is used as an immunological challenge in studies of mechanisms of immunotolerance.

Image Unavailable-BOSSBS-6318R-A350

Anti-SMPD1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-6318R-A350)
Supplier: Bioss
Description: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.
UOM: 1 * 100 µl
Image Unavailable-ICNA0215393205

Lactulose ~98%, white powder

Supplier: MP Biomedicals
Description: Lactulose is a synthetic, non-digestible sugar used in the treatment of chronic constipation and hepatic encephalopathy, a complication of liver disease. It is a disaccharide (double-sugar) formed from one molecule each of the simple sugars (monosaccharides) fructose and galactose.

Image Unavailable-SIALG7516-5G

Bovine gamma-globulin (from Blood)

Supplier: Merck
Description: γ-Globulin from bovine blood are categorised by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. It is used as an immunological challenge in studies of mechanisms of immunotolerance.

Product Image-STMC07900

Human, Mouse, Rat, Non-Human Primate Desoxyribonuclease I (DNase I)

Supplier: STEMCELL Technologies
Description: Use Deoxyribonuclease (DNase) I Solution (1 mg/ml) for routine tissue dissociation, minimizing clumping of concentrated and/or cryopreserved cell suspensions following thawing or enzymatic tissue digestion, and to eliminate DNA contaminants.

Product Image-BEHRB00217639

behrotest® nitrogen station, KOSTA 2

Catalog Number: (BEHRB00217639)
Supplier: BEHR
Description: In the behrotest® nitrogen station, solvent is evaporated under ambient temperature conditions by using a mild nitrogen flow. A distributor leads the nitrogen flow through two individually adjustable tubes into the Kuderna-Danish flasks. Thus the two samples reduce simulataneously.
UOM: 1 * 1 items
Product Image-PRSI27-961

Anti-PNLIP Rabbit Polyclonal Antibody

Catalog Number: (PRSI27-961)
Supplier: ProSci Inc.
Description: PNLIP is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas.
UOM: 1 * 100 µG
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
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The original product is no longer available. The replacement shown is available.
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