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Image Unavailable-BOSSBS-3812R

Anti-NEDD8 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-3812R)
Supplier: Bioss
Description: Ubiquitin like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin, RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other. In contrast to UBLs, UDPs are not proteolytically processed or conjugated to other proteins. Rub1 and the corresponding human homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, that forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to ubiquitin. The best known targets of Rub1 modification are members of the cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification may regulate SCF function or localization.
UOM: 1 * 100 µl
Product Image-BOSSBS-9430R

Anti-HSPB7 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9430R)
Supplier: Bioss
Description: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting.
UOM: 1 * 100 µl
Image Unavailable-MMMA1112733

DBI-SALA® ExoFit™ XE200 Comfort Rescue Safety Harnesses

Supplier: 3M
Description: Cross chest buckle assembly for central front fall arrest attachment point - optimised position on body. Revolving torso adjusters (patented) for quick and easy harness fit and adjustment. Auto-locking quick connect buckles secure contact with webbing, reducing the need to readjust.

Product Image-111-1389

Emergency rescue sling, Miller®

Catalog Number: (111-1389)
Supplier: HONEYWELL SAFETY
Description: Used by many leading rescue services around the world, this comfortable and easy to use rescue sling is based on a helicopter sling: The chest strap can be undone and fitted around the casualty while remaining attached to the rescue system.
UOM: 1 * 1 items
Product Image-113-8666

Work positioning lanyard, Miller® HandZup®

Supplier: HONEYWELL SAFETY
Description: The ergonomic HandZup® is a unique, patented work positioning system (EN 358) that leaves the hands free and enables the operator to work in complete safety.

Image Unavailable-BOSSBS-8497R-CY7

Anti-RENBP Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-8497R-CY7)
Supplier: Bioss
Description: RENBP is a 427 amino acid protein that is a proteinaceous renin inhibitor. In inhibiting renin, RENBP forms a complex with it; a high molecular weight renin. RENBP contains a leucine zipper domain, which is essential for its dimerization with renin. RENBP can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Sequences of porcine, human and rat renin-binding proteins are highly homologous. The RENBP gene is conserved in dog, mouse, rat and zebrafish, and maps to human chromosome Xq28 between DXS52 and G6PD. Rat Renbp is located on chromosome X at Xq37 close to marker DXWox3 and falls outside the BP QTL regions on chromosome X.
UOM: 1 * 100 µl
Image Unavailable-HAAK799-3001

Accessories for Falling Ball Viscometer

Supplier: HAAKE
Description: Falling ball viscometer

Product Image-CPSDAM450/100

Nylon webbing sling, Protecta®, DBI-SALA®, 3M™

Catalog Number: (CPSDAM450/100)
Supplier: CAPITAL SAFETY
Description: Polyester webbing slings are made from top quality materials guaranteeing high strength and durability. Can be used as versatile temporary anchorage solution.
UOM: 1 * 1 items
Product Image-CPSD2100094

Remote anchoring system, First-Man-Up™, DBI-SALA®, 3M™

Catalog Number: (CPSD2100094)
Supplier: CAPITAL SAFETY
Description: The telescopic rod connector allows to attach a rope life line above the user, enabling the user to ascend a pylon or to reach the top of a pole in complete safety.
UOM: 1 * 1 items
Product Image-113-1269

Harnesses, Titan™

Supplier: HONEYWELL SAFETY
Description: Non stretch harnesses for construction work. Available as a 1-point version with rear anchorage or as a 2-point version with front and rear anchorage.

Image Unavailable-BOSSBS-12867R-HRP

Anti-NR1H4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-12867R-HRP)
Supplier: Bioss
Description: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12867R-A488

Anti-NR1H4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-12867R-A488)
Supplier: Bioss
Description: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Product Image-115-2671

Work positioning lanyards, Protecta®, 3M™

Supplier: CAPITAL SAFETY
Description: Protecta® work positioning rope connecting lanyards are an ideal solution for the connecting element in a restraint system. Made from polyamide braided rope with safety stitching.

Product Image-113-8669

Safety device against suspension trauma, Miller Relief Step™ Safety Device

Catalog Number: (113-8669)
Supplier: HONEYWELL SAFETY
Description: The Miller Relief Step™ Safety Device alleviates the effects of orthostatic intolerance, also known as suspension trauma. If a fall occurs, a person becomes suspended in a harness and remains both vertical and sedentary for a period of time, causing blood to ‘pool’ in the veins of the legs. Subsequently, blood flow is restricted to the brain and other major organs that may initially result in unconsciousness. If not rescued promptly, serious injury or death may occur. The Miller Relief Step is designed to provide a short-term solution in preventing suspension trauma.
UOM: 1 * 1 items
Product Image-CPSD3504555

Self-retracting lifelines Ultra-Lok™, DBI-SALA®, 3M™

Catalog Number: (CPSD3504555)
Supplier: CAPITAL SAFETY
Description: Ultra-Lok™ web and cable SRLs are rugged, highly engineered devices that can be counted on for user safety, efficiency and reliability. Available with synthetic rope, stainless steel or galvanised steel cable and aluminium or thermoplastic housing.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-12867R-CY7

Anti-NR1H4 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-12867R-CY7)
Supplier: Bioss
Description: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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