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Image Unavailable-BOSSBS-3812R

Anti-NEDD8 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-3812R)
Supplier: Bioss
Description: Ubiquitin like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin, RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other. In contrast to UBLs, UDPs are not proteolytically processed or conjugated to other proteins. Rub1 and the corresponding human homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, that forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to ubiquitin. The best known targets of Rub1 modification are members of the cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification may regulate SCF function or localization.
UOM: 1 * 100 µl
Product Image-BOSSBS-9430R

Anti-HSPB7 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9430R)
Supplier: Bioss
Description: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting.
UOM: 1 * 100 µl
Product Image-HITA810-1325

VWR® Hitachi, Spare parts for HPLC pumps

Catalog Number: (HITA810-1325)
Supplier: VWR Collection
Description: These spare parts are suitable for certain HPLC pumps.
UOM: 1 * 1 items
Product Image-CPSD1500092

Spray can/bottle holster with Clip2Clip coil tether, DBI-SALA, 3M™

Catalog Number: (CPSD1500092)
Supplier: CAPITAL SAFETY
Description: Spray can/water bottle holster with coil tether.
UOM: 1 * 1 items
Product Image-MFLX01379-16

Masterflex® Plastic Ball Valves, Two-way Right Angle, Avantor®

Supplier: Avantor Fluid Handling
Description: Nonmetallic wetted parts ideal for water and mild aqueous solutions.

Product Image-MFLX01377-52

Masterflex® Plastic Ball Valves, Two-way Straight, PVC, Avantor®

Supplier: Avantor Fluid Handling
Description: Nonmetallic wetted parts ideal for water and mild aqueous solutions.

NSF international certified

Product Image-139-0218

Miller® MC03 Work Positioning Lanyard

Supplier: HONEYWELL SAFETY
Description: These lanyards are ideal for those who have to work at height in a supported hands-free position. The lanyard is passed around a supporting structure and connected to the side D-rings of the belt or harness.

Product Image-MFLX30600-04BLK

Smiths Medical® Luer Stopcock Fittings, Polycarbonate

Supplier: Avantor Fluid Handling
Description: Regulate flow without any leaking.

Product Image-CPSD1150491

Fall protection harness accessories, Protecta®, 3M™

Supplier: CAPITAL SAFETY
Description: Protecta® fall arrest harness accessory options provide the opportunity to add extra tool carrying convenience and comfort to a harness.

Product Image-MFLX30526-34

Masterflex® Luer Fittings, High-Pressure Stopcock, Avantor®

Catalog Number: (MFLX30526-34)
Supplier: Avantor Fluid Handling
Description: Pressure rating up to 1050 psi.
UOM: 1 * 10 items
Image Unavailable-BOSSBS-12867R-HRP

Anti-NR1H4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-12867R-HRP)
Supplier: Bioss
Description: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12867R-A488

Anti-NR1H4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-12867R-A488)
Supplier: Bioss
Description: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Product Image-113-8653

Fall protection harnesses, Miller H-Design® 2 pts harness Mating 2 loops

Supplier: HONEYWELL SAFETY
Description: Miller H-Design® two points harness with mating buckles on chest and legs straps and two sternal webbing loops. The Miller H-Design® harnesses are the new generation of harnesses dedicated to construction and general industry sectors providing more comfort, freedom of movements and safety to workers.

Product Image-CPSD3400881

Retrieval self-retracting lifeline, Sealed-Block™ DBI-SALA, 3M™

Supplier: CAPITAL SAFETY
Description: Sealed-Blok™ family has the most comprehensive line of sealed SRLs in the industry and decades of proven field service in the toughest environments.

Product Image-CPSD1500003

D-rings, DBI-SALA, 3M™

Catalog Number: (CPSD1500003)
Supplier: CAPITAL SAFETY
Description: D-rings can be attached to virtually any tool under 2,3 kg (5 lbs.) or 0,9 kg (2 lbs.) by using Quick-Wrap Tape.
UOM: 1 * 1 items
Product Image-PRTWFP13RER

Fall protection harnesses, 2 point

Catalog Number: (PRTWFP13RER)
Supplier: Portwest
Description: Fall Protection is put in place to prevent the risks associated with falling from heights, reducing impact force, restricting obstacle/ground collision and restricting users from fall hazard areas.
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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