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Image Unavailable-BOSSBS-15297R-A350

Anti-C8ORF58 Rabbit Polyclonal Antibody (ALEXA FLUOR® 350)

Catalog Number: (BOSSBS-15297R-A350)
Supplier: Bioss
Description: C8orf58 (chromosome 8 open reading frame 58) is a 365 amino acid protein that exists as two alternatively spliced isoforms, which are encoded by a gene that maps to human chromosome 8p21. Consisting of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13090R-A750

Anti-HER2 Tyr1221 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-13090R-A750)
Supplier: Bioss
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13089R-HRP

Anti-ERBB2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-13089R-HRP)
Supplier: Bioss
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13090R-CY3

Anti-ERBB2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-13090R-CY3)
Supplier: Bioss
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13090R-CY7

Anti-ERBB2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-13090R-CY7)
Supplier: Bioss
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13091R-A488

Anti-ERBB2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-13091R-A488)
Supplier: Bioss
Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13290R-A350

Anti-YEATS4 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-13290R-A350)
Supplier: Bioss
Description: Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13290R-A647

Anti-YEATS4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-13290R-A647)
Supplier: Bioss
Description: Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.
UOM: 1 * 100 µl
Product Image-PIER29139

Horseradish Peroxidase, Biotinylated, Pierce™

Catalog Number: (PIER29139)
Supplier: Thermo Fisher Scientific
Description: Biotinylated horse radish peroxidase is used as control or signal amplification in IHC to amplify the signal of biotinylated primary antibodies using the avidin-biotin complex staining method.
UOM: 1 * 5 mg
Image Unavailable-BOSSBS-1454R-A750

Anti-ErbB-3/HER3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-1454R-A750)
Supplier: Bioss
Description: The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterised. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterised.
UOM: 1 * 100 µl
Image Unavailable-J64400.03

DNA sodium salt (Deoxyribonucleic acid sodium salt) (from calf thymus)

Catalog Number: (J64400.03)
Supplier: Thermo Fisher Scientific
Description: Deoxyribonucleic acid sodium salt, is exceptionally useful as a substrate for DNA polymerase assays, in the amplification of very long fragments and as a carrier DNA for precipitations. Calf thymus DNA is exceptionally useful as a substrate for DNA polymerase assays, in the amplification of very long fragments and as a carrier DNA for precipitations. It was used as a standard to determine DNA content in gels and for DNA quantification by fluorescent assay.
UOM: 1 * 1 g

MSDS Certificates


Product Image-EDVOS-48

Ready-to-Load™ Kits, what is PCR and how does it work?

Catalog Number: (EDVOS-48)
Supplier: EDVOTEK
Description: This simulation experiment demonstrates the process of DNA amplification by PCR and how the amplified product is detected by separating the reaction mixture by agarose gel electrophoresis.
UOM: 1 * 1 KIT
Product Image-DALL1013530

Earmuffs, Impact Sport™

Catalog Number: (DALL1013530)
Supplier: HONEYWELL SAFETY
Description: Impact Sport™ earmuffs block harmful impact noise while enhancing user awareness of their environment through advanced sound amplification technology.
UOM: 1 * 1 items
Product Image-PIER21140

Streptavidin poly-HRP conjugate, Pierce™

Catalog Number: (PIER21140)
Supplier: Thermo Fisher Scientific
Description: Pierce™ Streptavidin Poly-HRP conjugate is biotin-binding protein conjugated with polymers of horseradish peroxidase, enabling signal amplification and detection of biotinylated antibodies for IHC and other methods.
UOM: 1 * 0,5 mL

MSDS


Product Image-710-1733

Real-Time PCR kit for detection of Listeria monocytogenes

Supplier: Q BIOANALYTIC
Description: OneCup it‘s so easy! The OneCup assay comes along with a minimum of pipetting steps. Everything is included in the mix. You only need to combine 20μl of the mix with 2 μl of your DNA sample and everything is ready. You have a minimum of hands-on time and you avoid mistakes during pipetting. You can run the test on all common block cyclers. Application: Detection of Listeria monocytogenes in food samples and environmental samples subsequent to a pre-enrichment step according to DIN EN ISO 20837 and 20838.Test principle. The test is dedicated to detect DNA of Listeria monocytogenes in a sample using Real-Time PCR in compliance with the ISO method mentioned below. The kit uses the TaqMan® principle. Thus the requirements of the standard, that an amplification product has to be confirmed by a hybridization step, is fulfilled. Each reactions contains an internal amplification control. Therefore, false negative results due to inhibition of the reaction can be excluded. The test included the UNG enzyme to prevent re-amplification of contaminating amplicons.

Product Image-PIER31030

High sensitivity NeutrAvidin™ protein-HRP conjugate, Pierce™

Supplier: Thermo Fisher Scientific
Description: Pierce™ High Sensitivity NeutrAvidin™-HRP Conjugate is a specially prepared peroxidase conjugated form of avidin biotin binding protein that provides signal amplification like poly-HRP and exceptional storage stability.

Certificates

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
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