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Image Unavailable-BOSSBS-5690R-A750

Anti-Rab24 Ser95 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-5690R-A750)
Supplier: Bioss
Description: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11235R-FITC

Anti-GRK4, GRK5, GRK6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-11235R-FITC)
Supplier: Bioss
Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6501R-CY7

Anti-RAB25 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-6501R-CY7)
Supplier: Bioss
Description: RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3048R-A680

Anti-beta Arrestin 1Ser412 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-3048R-A680)
Supplier: Bioss
Description: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-FITC

Anti-TROP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-1243R-FITC)
Supplier: Bioss
Description: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4228R-A647

Anti-VLDLR Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-4228R-A647)
Supplier: Bioss
Description: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
UOM: 1 * 100 µl
Product Image-461-0918

Heating circulators, CORIO™ CD-BC series

Supplier: JULABO GmbH
Description: The powerful and robust CORIO™ laboratory circulators provide the exact temperature, absolute precision, and a wide working temperature range. The CORIO™ CD model is an advanced unit with professional technology for demanding applications and can be used for temperature control of internal or external applications. The jet nozzle allows continuous adjustment of the pump stream in the system. The insulated stainless steel baths are durable and have an integrated drain tap. These heating circulators are optimised for external temperature applications in combination with jacketed reactors, distillation apparatus, mini-plant applications, photometers, refractometers and can also be used for internal temperature applications of samples and small objects.

Image Unavailable-BOSSBS-6501R-HRP

Anti-RAB25 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-6501R-HRP)
Supplier: Bioss
Description: RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6071R-A350

Anti-LRP12 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-6071R-A350)
Supplier: Bioss
Description: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
UOM: 1 * 100 µl
Product Image-479-2452

Nunc™ CryoTubes™ Linear Barcoded Tubes

Supplier: Thermo Fisher Scientific
Description: Simplify sample inventory. Thermo Scientific™ Linear barcoded tubes feature Thermo Scientific™ Nunc™ and Thermo Scientific™ Nalgene™ Cryotubes with directly printed barcodes that are more robust than labels. Choose from available noncustom options or call for customised options in a wide range of choices of code type, length and format.

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Product Image-132-3907

Shelving systems, Metromax

Supplier: Metro International
Description: Tough polymer construction, edges manufactured out of stainless steel.

Image Unavailable-BOSSBS-5038R-CY7

Anti-APOE Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-5038R-CY7)
Supplier: Bioss
Description: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl
Product Image-611-3677

VWR® TA Professional, Analytical Balances with Touch Screen

Supplier: VWR Collection
Description: Laboratory analytical balances that have 5" colour touch screen display with advanced applications and large databases for professional weighing. The user has easy and intuitive access to balance functions, via interactive, icon-driven menus ensuring efficient and productive weighing. Balances can be used by up to 10 different users, each with their own customisable settings and password protection. Ideal for laboratories requiring GLP compliance. All models have a stainless steel top pan.

Image Unavailable-BOSSBS-0676R-FITC

Anti-FGFR4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-0676R-FITC)
Supplier: Bioss
Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5141R-A488

Anti-MATR3 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-5141R-A488)
Supplier: Bioss
Description: Matrin 3 (MATR 3) is an internal nuclear matrix protein that may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer MATR 3 may play a role in nuclear retention of defective RNAs. MATR3 forms part of complex consisting of SFPQ, NONO and MATR3.The protein contains 1 matrin type zinc finger and 2 RRM (RNA recognition motif) domains. Two transcript variants encoding the same protein have been identified for this gene.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5141R-CY5.5

Anti-MATR3 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-5141R-CY5.5)
Supplier: Bioss
Description: Matrin 3 (MATR 3) is an internal nuclear matrix protein that may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer MATR 3 may play a role in nuclear retention of defective RNAs. MATR3 forms part of complex consisting of SFPQ, NONO and MATR3.The protein contains 1 matrin type zinc finger and 2 RRM (RNA recognition motif) domains. Two transcript variants encoding the same protein have been identified for this gene.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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