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Image Unavailable-BOSSBS-0115R-CY7

Anti-AKT1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-0115R-CY7)
Supplier: Bioss
Description: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13141R-CY7

Anti-FANCD2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-13141R-CY7)
Supplier: Bioss
Description: Fanconi Anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANC D2, targeting nuclear foci containing the BRCA 1 protein.
UOM: 1 * 100 µl
Image Unavailable-ENZOADI905770100

Anti-CHK1 Mouse Monoclonal Antibody

Catalog Number: (ENZOADI905770100)
Supplier: ENZO LIFE SCIENCES
Description: The DNA damage checkpoint is a signal transduction pathway that has the ability to delay entry into mitosis. When DNA is damaged, the Check point kinases (CHKs) are known to act downstream of ATM to elicit appropriate responses such as cell cycle arrest. Chk1, for instance, is activated by ATM phosphorylation of serines 123, 178, 278, and 292 of the S phase-promoting cdc25A phosphatase and accelerates IR (ionizing radiation)induced degradation of cdc25A.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-3185R-A555

Anti-H2AFX Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-3185R-A555)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3185R-CY5

Anti-H2AFX Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-3185R-CY5)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3185R-A647

Anti-H2AFX Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-3185R-A647)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8571R-A350

Anti-H2AFX Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-8571R-A350)
Supplier: Bioss
Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
UOM: 1 * 100 µl
Image Unavailable-ENZOBMLEI3880010

BML-277 Chk2 inhibitor ≥98% (by TLC)

Catalog Number: (ENZOBMLEI3880010)
Supplier: ENZO LIFE SCIENCES
Description: BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.
UOM: 1 * 10 mg
Image Unavailable-BOSSBS-4920R-A750

Anti-Escherichka coli K99 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-4920R-A750)
Supplier: Bioss
Description: Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0,5 to 1,5 micrometers and numbering 100 to 300 per cell, enable bacteria to colonise the epithelium of specific host organs. FanC is the main component of the K99 fimbriae.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3542R-A680

Anti-PNK1/PNKP Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-3542R-A680)
Supplier: Bioss
Description: Mammalian PNK catalyses the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. It plays an important function in DNA repair following ionizing radiation or oxidative damage.PNK has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7703R-A750

Anti-TSPYL5 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-7703R-A750)
Supplier: Bioss
Description: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
UOM: 1 * 100 µl
Product Image-NABEL-055H3ANLGT

Muffle furnaces with lift up door, Tmax 1300 °C and standard controller B510, LT 5/13 - LT 15/13

Supplier: NABERTHERM
Description: These furnaces feature heating elements on supporting tubes that radiate freely into the chamber, ensuring particularly short heating times. With the robust lightweight refractory brick insulation, they can reach a max. working temperature of 1300 °C.

Product Image-JSPAAFN060-000-000

Splash guard, without impact protection, Force®8

Catalog Number: (JSPAAFN060-000-000)
Supplier: JSP
Description: The Force®8 Splash Guard can be fitted to a Force®8 half mask to reduce the likelihood of exhaled bacteria/virus hitting the wearer's face.
UOM: 1 * 10 items
Image Unavailable-BOSSBS-3015R

Anti-FANCD2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-3015R)
Supplier: Bioss
Description: Fanconi Anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation. DNA damage activates the monoubiquitination of FANC D2, targeting nuclear foci containing the BRCA 1 protein.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0278R-A680

Anti-RRAD Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-0278R-A680)
Supplier: Bioss
Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0278R-A750

Anti-RRAD Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-0278R-A750)
Supplier: Bioss
Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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