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Catalog Number: (BOSSBS-13664R-A350)
Supplier: Bioss
Description: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.
UOM: 1 * 100 µl


Catalog Number: (ANTIA90820-100)
Supplier: ANTIBODIES.COM
Description: Anti-NOC4L Rabbit Polyclonal Antibody
UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-7822R)
Supplier: Bioss
Description: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-10156R-CY3)
Supplier: Bioss
Description: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11444R-CY3)
Supplier: Bioss
Description: Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11444R-CY7)
Supplier: Bioss
Description: Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-10156R-CY5)
Supplier: Bioss
Description: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11444R-CY5)
Supplier: Bioss
Description: Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
UOM: 1 * 100 µl


Catalog Number: (USBI039073-BIOTIN)
Supplier: US Biological
Description: Anti-NOX5 Rabbit Polyclonal Antibody (Biotin)
UOM: 1 * 200 µl


Catalog Number: (BOSSBS-10156R-CY7)
Supplier: Bioss
Description: Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.
UOM: 1 * 100 µl


Catalog Number: (USBI033738-BIOTIN)
Supplier: US Biological
Description: Anti-CE037 Rabbit Polyclonal Antibody (Biotin)
UOM: 1 * 200 µl


Catalog Number: (ORIGTA311523)
Supplier: OriGene
Description: Anti-NOX5 Goat Antibody
UOM: 1 * 100 µG


Catalog Number: (ANTIA78439-96)
Supplier: ANTIBODIES.COM
Description: Human NOX5 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human NOX5 in serum, plasma, tissue homogenates, and other biological fluids.
UOM: 1 * 96 Tests

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Catalog Number: (ANTIA313459-96)
Supplier: ANTIBODIES.COM
Description: Human NOX5 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human NOX5 in serum, plasma, and other biological fluids.
UOM: 1 * 96 Tests

New Product


Catalog Number: (USBI043530-APC)
Supplier: US Biological
Description: Anti-UBE2Q1 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM: 1 * 200 µl


Catalog Number: (BIRBORB103113-100)
Supplier: Biorbyt
Description: Anti-NOC2L Rabbit Polyclonal Antibody (FITC (Fluorescein))
UOM: 1 * 100 µG


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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