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Image Unavailable-BOSSBS-9173R-FITC

Anti-RNF8 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-9173R-FITC)
Supplier: Bioss
Description: The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase. It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation. The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, and they co-localize in the nucleus. RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains. RNF8 also binds to Retinoid X receptor alpha (RXR?, a member of the steroid hormone receptor superfamily. It increases RXR?mediated transactivation of the RXR?responsive element (RXRE) promoter in a dose-dependent manner, suggesting that RNF8 is a regulator of RXR?mediated transcriptional activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9145R

Anti-UBOX5 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9145R)
Supplier: Bioss
Description: The U-box domain is a modified RING finger motif that has been implicated in the ubiquitin/proteasome system. The ubiquitin-conjugating enzyme 7-interacting protein 5 (UIP5), also designated U-box domain-containing protein 5 or RING finger protein 37, contains 1 RING-type zinc finger and 1 U-box domain. UIP5 has been shown to interact with UBCH7, an enzyme that mediates selective degradation of abnormal proteins. The gene encoding UIP5 maps to chromosome 20, which houses over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
UOM: 1 * 100 µl
Image Unavailable-ESCH1154

Aspheric Stand Magnifier, 10×

Catalog Number: (ESCH1154)
Supplier: ESCHENBACH OPTIK
Description: Provides a clear, distortion-free image, with exchangeable precision measuring scales for various applications and allows fine focusing via handy focusing ring.
UOM: 1 * 1 Each

New Product


Product Image-132-1407

VWR® Economy Line 2.0, Laboratory Chairs

Supplier: VWR Collection
Description: Economy line 2.0 is a simple laboratory chair that still meets all requirements that a laboratory implies. The chair is ergonomic, robust, easy to clean, intuitive to use and has an excellent price-performance ratio.

Product Image-COWI005.0.0824.PK

Shaft guides, High Performance (HP), for standard taper ground glass joints

Supplier: COWIE
Description: High Performance (HP) shaft guides provide an effective guide for use with glass and metal shaft stirrers over a wide range of temperatures without shedding particles from a specially formulated PTFE-PEEK seal whilst maintaining vacuum. The moulded-in PTFE-PEEK guide ring located at the end of the taper provides a guide to assist alignment of the shaft.

Image Unavailable-BOSSBS-9258R

Anti-RNF165 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9258R)
Supplier: Bioss
Description: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in protein-protein interactions and protein-DNA interactions. Specifically, they are thought to be involved in the ubiquitination pathway of protein degradation. RNF165 (RING finger protein 165) is a 346 amino acid protein that contains one RING-type zinc finger. Via its RING-type zinc finger, RNF165 may play a role in transcriptional regulation and protein degradation events. The gene encoding RNF165 maps to human chromosome 18, which houses over 300 genes, including Trisomy 18, or Edwards syndrome, the second most common trisomy after Downs syndrome. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are also associated with chromosome 18.
UOM: 1 * 100 µl
Product Image-705-0717

Accessories for Turb® 550 and 555

Supplier: WTW
Description: Accessory for turbidity meter, Turb®, Calibration set (0,02;10;1000 NTU) with cleaning tissues and indexing rings, For: 550

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Image Unavailable-BOSSBS-9340R-HRP

Anti-MARCH6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-9340R-HRP)
Supplier: Bioss
Description: MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6142R

Anti-RING1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-6142R)
Supplier: Bioss
Description: This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
UOM: 1 * 100 µl
Product Image-514-0324

VWR®, Accessories for Bottle Top Filtration Systems

Catalog Number: (514-0324)
Supplier: VWR Collection
Description: Bottle top filter, VWR®, Cradle ring
UOM: 1 * 1 items
Image Unavailable-N5514-10TAB

Nitro blue tetrazolium chloride (NBT), tablets, Sigma-Aldrich®

Supplier: SIGMA ALDRICH MICROSCOPY
Description: Nitro Blue Tetrazolium is a tetrazole compound with two tetrazole rings.

Product Image-511-0352

Gas distribution tubes, VitraPOR®

Supplier: ROBU GLASFILTER
Description: These versatile and recyclable tubes offer excellent properties for diverse applications are made of borosilicate glass 3.3.

Product Image-LENZ01102519

Alu rings with hooks for conical joints

Supplier: Lenz Laborglas GmbH & CO.KG
Description: These alu rings with hooks are for cones and sockets to be used with springs for the safe connection of conical ground joints. No breakage of glass hoods.

Image Unavailable-BOSSBS-9230R-CY5

Anti-RNF158 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-9230R-CY5)
Supplier: Bioss
Description: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. SH3RF2 (SH3 domain containing ring finger 2), also known as RNF158, is a 729 amino acid protein with one RING-type zinc finger domain and three SH3 domains. Via its RING-type zinc finger domain, SH3RF2 binds an E2 ubiquitin-conjugating enzyme. This suggests that SH3RF2 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. Due to alternative splicing events, SH3RF2 is expressed as two different isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9240R

Anti-RNF25 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9240R)
Supplier: Bioss
Description: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9173R-CY7

Anti-RNF8 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-9173R-CY7)
Supplier: Bioss
Description: The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase. It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation. The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, and they co-localize in the nucleus. RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains. RNF8 also binds to Retinoid X receptor alpha (RXR?, a member of the steroid hormone receptor superfamily. It increases RXR?mediated transactivation of the RXR?responsive element (RXRE) promoter in a dose-dependent manner, suggesting that RNF8 is a regulator of RXR?mediated transcriptional activity.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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