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Capillary columns, Rapid-MS

Supplier: VARIAN
Description: Rapid-MS columns reduce analysis duration by 3 to 5 times for temperature programmed, and up to 10 times for isothermal runs.

Image Unavailable-VELP40003081

Preventive Maintenance (PM) Kit

Catalog Number: (VELP40003081)
Supplier: VELP SCIENTIFIC
Description: The PM full is designed to keep your running with high performances while ensuring long life and reliability, even under high workloads.
UOM: 1 * 1 KIT

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Product Image-BE-417

Experimentation kits, affinity chromatography

Catalog Number: (BE-417)
Supplier: G-Biosciences
Description: The Affinity Chromatography kit teaches the basic principle of affinity chromatography utilising highly specific affinity columns. This lab activity involves preparation of a crude protein extract and running affinity exchange chromatography for isolation of a protein.
UOM: 1 * 1 KIT
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Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: BP53-12]

Supplier: Biotium
Description: This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

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Anti-TP53 Rabbit Monoclonal Antibody (Purified) [clone: PAb122]

Supplier: Biotium
Description: PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.

Product Image-THSASRF110P2-230

SpeedVac™ SRF110 Refrigerated Centrifugal Vacuum Concentrator

Supplier: THERMO SAVANT
Description: SpeedVac™ SRF110 modular refrigerated vacuum concentrator provides flexibility to your lab. It offers unique programming capabilities to maintain chamber temperature pre and post sample run to prevent thermal degradation of heat sensitive samples such as proteins, enzymes, and other biomolecules.

Product Image-HPLT50118908

Magnetic stirrers, variomag mobil 200, Cimarec™

Supplier: THERMO H + P LABORTECHNIK
Description: Magnetic stirrer with external control, units are ideal for stirring large volumes and integration in analytical instruments and systems. Quick Stop function stops the drive within three seconds, minimizing after runs and risk of vessel breakage.

Image Unavailable-BNC940013-500

Anti-TP53 Mouse Monoclonal Antibody (CF594) [clone: BP53-12]

Supplier: Biotium
Description: This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

Product Image-HYPE6PRV11-1PT

Glass snap top vials, 2 ml, level 3 high performance applications, SureSTART™

Supplier: Thermo Fisher Scientific
Description: Choose Thermo Scientific™ SureSTART™ 2 ml glass snap top vials, performance level 3, for high performance applications, when sensitivity is a must, and when you are running many samples.

Product Image-ELET36630-00

Cole-Parmer® Integrity 10 Reaction Station

Catalog Number: (ELET36630-00)
Supplier: Cole-Parmer
Description: Use the Integrity 10 reaction station to run ten independent experiments at once. By setting the temperature and stir rate individually for each cell users can assess the impact of both at the same time, speeding up investigative chemistry by ten-fold.
UOM: 1 * 1 items
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Anti-TP53 Mouse Monoclonal Antibody (CF647) [clone: BP53-12]

Supplier: Biotium
Description: This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

Product Image-730-2202

Well visualisation plates

Supplier: EMBITEC
Description: RunOne™ well visualisation plates are designed to make gel loading simple. The light colour of most gel units provides little or no contrast for the agarose gel and the gel wells. RunOne™ well visualisation plates are red, fit securely into the RunOne™ system, and provide a stable platform for gel running.

Product Image-USBI041338

Anti-SGSM2 Rabbit Polyclonal Antibody

Catalog Number: (USBI041338)
Supplier: US Biological
Description: Anti-SGSM2 Rabbit Polyclonal Antibody
UOM: 1 * 200 µl
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Phosphate Buffer, pH 6.6 at 25 °C

Supplier: SIGMA ALDRICH MICROSCOPY
Description: Phosphate buffer's buffering capacity is pH sensitive and is preferred to be used at physiological pH (7,2 to 7,4).

Product Image-BE-414

Experimentation kits, size exclusion chromatography

Catalog Number: (BE-414)
Supplier: G-Biosciences
Description: The Size Exclusion Chromatography kit teaches gel filtration or size exclusion chromatography and the use of this method in purification of biological samples. This method is based on separation of protein molecules based on their molecular size. This lab activity involves running size exclusion chromatography for separation of molecules based on their molecular sizes.
UOM: 1 * 1 KIT
Product Image-733-2892

qPCR cycler, Q

Supplier: Quantabio
Description: Q qPCR cycler uses a patented magnetic induction technology to rapidly heat samples, coupled with fan-forced air for cooling to acquire data in only 25 minutes. Available as four channel models, the robust optical system acquires all channels simultaneously and allows for running the fastest multiplexed assays.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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