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Image Unavailable-BOSSBS-4000R-A680

Anti-CHK2 ser19 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
Catalog Number: BOSSBS-4000R-A680
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-5275R-A647

Anti-CHEK2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
Catalog Number: BOSSBS-5275R-A647
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-5275R-A750

Anti-CHK2 Thr387 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.
Catalog Number: BOSSBS-5275R-A750
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-SIALS153-25MG

SQ 22,536 ADENYLATE CYCLASE INH 1 * 25 mg

Description: SQ 22,536 ADENYLATE CYCLASE INH 1 * 25 mg
Catalog Number: SIALS153-25MG
UOM: 1 * 25 mg
Supplier: Merck
Image Unavailable-CAYM13339-50

SQ 22,536 (50 mg) 1 * 50 mg

Description: SQ 22,536 (50 mg) 1 * 50 mg
Catalog Number: CAYM13339-50
UOM: 1 * 50 mg
Supplier: Cayman Chemical
Image Unavailable-CAYM13339-25

SQ 22,536 (25 mg) 1 * 25 mg

Description: SQ 22,536 (25 mg) 1 * 25 mg
Catalog Number: CAYM13339-25
UOM: 1 * 25 mg
Supplier: Cayman Chemical
Product Image-ENTEH201003262C02

TRAY - CHIP SQ PKTS H20-100-32-62C02 Material: STAT-PRO 150 (Black Conductive Polypropylene) Pocket Dimensions: 2.54mm x 2.54mm x 0.81mm Capacity: 10x10 (100) 1 * 100 ST

Description: TRAY - CHIP SQ PKTS H20-100-32-62C02 Material: STAT-PRO 150 (Black Conductive Polypropylene) Pocket Dimensions: 2.54mm x 2.54mm x 0.81mm Capacity: 10x10 (100) 1 * 100 ST
Catalog Number: ENTEH201003262C02
UOM: 1 * 100 items
Supplier: ENTEGRIS
Image Unavailable-MILLSQPAKACARE

The SQPAK Care A Cleaner prevents scaling in the Milli-Q SQ 2Series production station. The purification technology of the SQPAK Care A - Acid Cleaner includes an acidic reagent to remove mineral scaling in hydraulic parts null

Description: The SQPAK Care A Cleaner prevents scaling in the Milli-Q SQ 2Series production station. The purification technology of the SQPAK Care A - Acid Cleaner includes an acidic reagent to remove mineral scaling in hydraulic parts null
Catalog Number: MILLSQPAKACARE
UOM:
Supplier: Merck

New Product


Image Unavailable-APOSOR46244-25G

2-Chloro-5-methylpyrimidine 98%

Description: 2-Chloro-5-methylpyrimidine 98%
Catalog Number: APOSOR46244-25G
UOM: 1 * 25 g
Supplier: Apollo Scientific
Product Image-ACRO454040010

2,5-Dichloropyrimidine 95%

Description: 2,5-Dichloropyrimidine 95%
Catalog Number: ACRO454040010
UOM: 1 * 1 g
Supplier: Thermo Fisher Scientific

MSDS


Product Image-ACRO426820010

2-Chloro-4-methoxypyrimidine 98%

Description: 2-Chloro-4-methoxypyrimidine 98%
Catalog Number: ACRO426820010
UOM: 1 * 1 g
Supplier: Thermo Fisher Scientific

MSDS


Image Unavailable-APOSOR46001-100G

2-Chloro-4-methoxypyrimidine

Description: 2-Chloro-4-methoxypyrimidine
Catalog Number: APOSOR46001-100G
UOM: 1 * 100 g
Supplier: Apollo Scientific
Image Unavailable-APOSOR30544-500MG

2-Chloropyrimidine-4-carboxamide

Description: 2-Chloropyrimidine-4-carboxamide
Catalog Number: APOSOR30544-500MG
UOM: 1 * 500 mg
Supplier: Apollo Scientific
Image Unavailable-APOSOR938765-250MG

2-Chloro-5-phenylpyrimidine 95%

Description: 2-Chloro-5-phenylpyrimidine 95%
Catalog Number: APOSOR938765-250MG
UOM: 1 * 250 mg
Supplier: Apollo Scientific
Image Unavailable-H64773.14

2-Chloro-5-methylpyrimidine 97%

Description: 2-Chloro-5-methylpyrimidine 97%
Catalog Number: H64773.14
UOM: 1 * 25 g
Supplier: Thermo Fisher Scientific

Certificates


Image Unavailable-APOSOR17514-25G

2,5-Dichloropyrimidine 97+%

Description: 2,5-Dichloropyrimidine 97+%
Catalog Number: APOSOR17514-25G
UOM: 1 * 25 g
Supplier: Apollo Scientific
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