You Searched For: TLC+Sorbents

Supplier: ENZO LIFE SCIENCES

Description: Chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Suppresses self-renewal of embryonic stem cells.

Supplier: Thermo Fisher Scientific

Description: A medium polarity sorbent, Thermo Scientific™ HyperSep™ Cyano Plates are less retentive than silica or diol, and are optimized for the isolation of polar compounds from nonpolar matrices.

Supplier: ENZO LIFE SCIENCES

Description: Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

Catalog Number: (ENZOBMLT1090001)

Supplier: ENZO LIFE SCIENCES

Description: Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.

UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES

Description: Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

Supplier: ENZO LIFE SCIENCES

Description: Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.

Catalog Number: (ENZOBMLEI2520005)

Supplier: ENZO LIFE SCIENCES

Description: RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.

UOM: 1 * 5 mg

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Catalog Number: (90092.)

Supplier: Biotium

Description: Fluorescamine is nonfluorescent until it reacts with primary amines. The reaction is completed in miniseconds and can be used to detect amine-containing compounds including peptides and proteins. Unreacted fluorescamine is rapidly converted to a non-fluorescent product by reaction with water, making amine detection highly specific.

UOM: 1 * 100 mg

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Catalog Number: (50007.)

Supplier: Biotium

Description: Dimethyl BAPTA AM ester is a membrane permeable form of Dimethyl BAPTA that can be loaded into cells by incubation. Dimethyl BAPTA AM ester itself does not bind calcium, but once inside the cell is converted into Dimethyl BAPTA by cytoplasmic esterases.

UOM: 1 * 25 mg

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Supplier: VARIAN

Description: Native silica is generally regarded as the most polar SPE sorbent available. Bond Elut™ SI is particularly effective at separating compounds with a very similar structure. Applying the analytes in a non-polar solvent, then increasing the solvent polarity by increasing the concentration of a polar modifier, such as THF or ethyl acetate, delivers effective separations.

Catalog Number: (8111-04)

Supplier: Avantor

Description: These columns feature BAKERBOND® DVB polymer resins, which are the product of ultra-clean polymer microparticle technology. These resin particles have a large surface area, are highly rigid, are stable over pH range 1 to 14, are water-wettable and are not impacted by sorbent drying. These columns are recommended when advanced detection methods are used.

UOM: 1 * 1 items

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Catalog Number: (ENZOBMLEI3610001)

Supplier: ENZO LIFE SCIENCES

Description: A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

UOM: 1 * 1 mg

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Supplier: witeg Labortechnik

Description: Round shaped chambers made of borosilicate glass.

Catalog Number: (552-0217)

Supplier: MACHEREY-NAGEL

Description: Glass plates with mixed layers for TLC.

UOM: 1 * 25 items

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Catalog Number: (ENZOBMLPG0020010)

Supplier: ENZO LIFE SCIENCES

Description: Blocks cell cycle at the G1 and G2/M phase [1] by inhibiting G1 phase cyclin dependent kinases [2] downregulating cyclin D1 [3]. Modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, glutathione S-transferase activity and transport of GSH conjugates [4]. Antitumor activity. Induces γ-glutamylcysteine synthetase and apoptosis in L-1210 cells.

UOM: 1 * 10 mg

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Supplier: Avantor

Description: These columns feature BAKERBOND® DVB polymer resins, which are the product of ultra-clean polymer microparticle technology. These resin particles have a large surface area, are highly rigid, are stable over pH range 1 to 14, are water-wettable and are not impacted by sorbent drying. These columns are recommended when advanced detection methods are used.

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