You Searched For: TLC+Sorbents

Supplier: ENZO LIFE SCIENCES

Description: DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific™ HyperSep Aminopropyl SPE 96-Well Plates and Individual Wells feature a polar sorbent that allows both polar and anion exchange interactions. The chemistry offers good retention of drugs, metabolites and structural isomers.

Supplier: ENZO LIFE SCIENCES

Description: Potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun, induction of c-Jun transcription and anti CD3-induced apoptosis of CD4+ CD8+ thymocytes.

Supplier: ENZO LIFE SCIENCES

Description: Potent, selective and irreversible inhibitor of MAG lipase (IC50=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.

Catalog Number: (ENZOBMLEI3080001)

Supplier: ENZO LIFE SCIENCES

Description: HSP90 inhibitor

UOM: 1 * 1 mg

Sale

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific™ HyperSep SCX Strong Cation Exchanger SPE 96-Well Plates and Individual Wells feature a strong cation exchange sorbent for extraction of charged basic compounds. The use of SPE sample preparation can significantly enhance the robustness and reliability of many biological, pharmaceutical, forensic and environmental applications.

Catalog Number: (ENZOBMLEI3270025)

Supplier: ENZO LIFE SCIENCES

Description: URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

UOM: 1 * 25 mg

Sale

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific™ HyperSep Silica SPE 96-Well Plates and Individual Wells feature a polar sorbent primarily used to retain analytes in non polar matrices, and can effectively separate compounds of very similar structure.

Catalog Number: (552-0007)

Supplier: CAMAG

Description: The Nanomat 4 is used for easy application of samples in the form of spots onto TLC and HPTLC layers. A notch system ensures that sample positioning meets the requirements for automatic scanning with a densitometer. Samples are dispensed in volumes of 0,5 to 5 µl with disposable capillaries loaded into the universal capillary holder (552-0044) using the capillary guide (552-0039).

UOM: 1 * 1 items

Sale

Supplier: VARIAN

Description: Bond Elut™ Jr cartridges have top and bottom Luer fittings allowing easy sample processing when used in conjunction with standard SPE cartridges. Bond Elut™ LRC cartridges have a large reservoir above the sorbent bed and are suitable for use on any standard SPE vacuum manifold.

Supplier: Agilent

Description: Step 2: Dispersive SPE cleanup
Select the dispersive SPE kit suited to the type of food being analysed and the method you are following. In this step, an aliquot of the sample extract from step one (see QuEChERS extraction kits) is added to a 2 or 15 ml centrifuge tube containing a small amount of SPE sorbent and MgSO₄. The sorbent will pull out interfering matrix materials from the sample, while the MgSO₄ helps remove excess water and improve analyte partitioning.

Catalog Number: (59003.)

Supplier: Biotium

Description: TPEN (Tetrakis-(2-pyridylmethyl)ethylenediamine) is an excellent heavy metal chelator while it does not affect Ca2 , Mg2 , Na , or K concentrations. Thus, TPEN is a useful tool to identify effects of heavy metals (Zn2 , Fe2 /Fe3 , Cu2 , and Mn2 , etc.) on fluorescent indicators of Ca2 , Mg2 , Na , or K .

UOM: 1 * 100 mg

Sale

Supplier: ENZO LIFE SCIENCES

Description: HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

Supplier: ENZO LIFE SCIENCES

Description: HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).

Supplier: MACHEREY-NAGEL

Description: These native fibrous cellulose layers are available as glass plates, POLYGRAM® polyester sheets and ALUGRAM® aluminium sheets. They are used in partition chromatography of polar substances such as for the separations of amino acids, carboxylic acids or carbohydrates.

Supplier: MACHEREY-NAGEL

Description: Thin-layer chromatography plates (TLC), POLYGRAM®, POLYGRAM® TLC polyester sheets CEL 300, Coating material: Cellulose, Backing material: Polyester, Fluorescent indicator: No, Plate size: 40×80 mm