You Searched For: WLD-TEC+GmbH

Catalog Number: (BOSSBS-2752R-HRP)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-2752R-FITC)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-2752R-A350)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-2752R-A647)

Supplier: Bioss

Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

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Supplier: THARMAC GmbH

Description: Charcoal filter for fume hoods, Cellstain®

Catalog Number: (201-0126)

Supplier: Lenz Laborglas GmbH & CO.KG

Description: PTFE, white.

UOM: 1 * 1 items

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Supplier: Lenz Laborglas GmbH & CO.KG

Description: Support, complete with clamps and connectors

Supplier: Lenz Laborglas GmbH & CO.KG

Description: Borosilicate glass.

Supplier: Lenz Laborglas GmbH & CO.KG

Description: DURAN®, borosilicate glass.

Catalog Number: (LENZ400308)

Supplier: Lenz Laborglas GmbH & CO.KG

Description: Separating Funnels, PA, Capacity: 25 ml, Socket size: 19/16 NS

UOM: 1 * 1 items

Sale

Supplier: THARMAC GmbH

Description: Fume hood with activated charcoal filter, Cellstain®

Supplier: ATLAS - the shoe company

Description: Lightweight ESD safety shoe made from Sportline upper (oiled nubuck leather), safety reflectors and a MPU® Light sole (3,5 mm profile, oil, acid and petrol resistant, anti-static).

Supplier: THARMAC GmbH

Description: Closed rotor JC105/12 with Quickchange 12-position, For: Cyto centrifuges

Supplier: Lenz Laborglas GmbH & CO.KG

Description: Solid soda-lime glass.

Supplier: Lenz Laborglas GmbH & CO.KG

Description: DURAN®, borosilicate glass.

Supplier: Lenz Laborglas GmbH & CO.KG

Description: Duran® clear borosilicate glass.