You Searched For: orf1a

Supplier: Novus Biologicals

Description: Anti-HIF1A Rabbit Polyclonal Antibody

Catalog Number: (PRSI33-139)

Supplier: ProSci Inc.

Description: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

UOM: 1 * 100 µG

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Catalog Number: (USBI150162)

Supplier: US Biological

Description: Anti-ASF1A Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (ABGEAP14481A)

Supplier: Abgent

Description: Anti-OR4F3 Rabbit Polyclonal Antibody

UOM: 1 * 400 µl

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Supplier: Abcam

Description: Rabbit monoclonal [EPR24850-55] to SARS-CoV-2 orf7a - BSA and Azide free.

Catalog Number: (BIRBORB44775-0.1)

Supplier: Biorbyt

Description: Anti-N. meningitidis antigen Orf1 Rabbit Polyclonal Antibody

UOM: 1 * 0,1 mg

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Catalog Number: (ABCAAB303593-100)

Supplier: Abcam

Description: Alexa Fluor® 647 Rabbit monoclonal [EPR21844-108] to LINE-1 ORF1p.

UOM: 1 * 100 µl

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Supplier: Abcam

Description: Rabbit monoclonal [EPR24848-9] to SARS CoV-2 ORF3a Protein - BSA and Azide free.

Catalog Number: (BOSSBS-8680R-CY3)

Supplier: Bioss

Description: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-8680R-CY5)

Supplier: Bioss

Description: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-1405R)

Supplier: Bioss

Description: Anti-TCF1/HNF1A Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalog Number: (USBIT2020-22-BIOT)

Supplier: US Biological

Description: Anti-HNF1A Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

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Catalog Number: (USBI039316-BIOTIN)

Supplier: US Biological

Description: Anti-OR11A1 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

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Catalog Number: (BOSSBS-0737R-CY5)

Supplier: Bioss

Description: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

UOM: 1 * 100 µl

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Catalog Number: (NOVUNBP1-47180B)

Supplier: Novus Biologicals

Description: Anti-HIF1A Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 0,1 mL

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Catalog Number: (BOSSBS-0737R-CY3)

Supplier: Bioss

Description: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

UOM: 1 * 100 µl

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