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Image Unavailable-BOSSBS-6634R-A647

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-6634R-A647)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Product Image-MFLX72072-30

LeviFlow Single-Use Centrifugal Pump Accessories

Supplier: Avantor Fluid Handling
Description: Optimize performance of your Levitronix Centrifugal Pump.

CE Compliant

Product Image-SCOI285103553

Platinum electrode, ScienceLine

Catalog Number: (SCOI285103553)
Supplier: SI Analytics
Description: Single platinum electrode, with glass shaft and ring shaped sensor (Ø 6 mm). For titration purposes.
UOM: 1 * 1 items
Product Image-MFLX31201-64

Masterflex® Single-Use Sanitary Gaskets, TPE, Avantor®

Supplier: Avantor Fluid Handling
Description: Ensure a tight seal in your sanitary fluid line.

Certificates 3A Sanitary approval

Image Unavailable-D9564-10MG

4',6'-Diamidino-2-phenylindole dilactate (DAPI dilactate) ≥98% (by HPLC) used in nuclear staining, Sigma-Aldrich®

Catalog Number: (D9564-10MG)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: A high sensitivity dye used to detect single nucleic acid molecules. DAPI has been shown to detect a single DNA molecule in solution, and to detect femtograms of DNA in single cells and chloroplasts.
UOM: 1 * 10 mg
Product Image-734-3323

VWR®, Single-Use Transfer Hose with SterilEnz™ Connections

Supplier: VWR Collection
Description: Avantor's high pressure single-use transfer hose with Avantor SterilEnz™ connections maintain the durability of high pressure hose products while providing the benefits and flexibility of single-use assemblies.

Product Image-MFLX76000-00

Masterflex® Single-Use Replacement Pump Heads for Quattroflow Pump Systems

Supplier: Avantor Fluid Handling
Description: Keep your Quattroflow™ pump system up and running with these quality replacement pump heads.

Image Unavailable-734-3341

VWR®, Accessories for Avantor TopMixer Single-Use Open Top Mixing Systems

Supplier: VWR Collection
Description: Single-Use LDPE tank with bottom port, 50L, VWR®

Product Image-MFLX19999-96

Masterflex® Single Use Tubing Pinch Clamps, Avantor®

Catalog Number: (MFLX19999-96)
Supplier: Avantor Fluid Handling
Description: Clamps are double bagged and ready for use in your cleanroom environment.
UOM: 1 * 1 items

Certificates CE certificate


Product Image-MFLX30719-04

Masterflex® Single-Use Filling Needles

Supplier: Avantor Fluid Handling
Description: A high-quality engineered solution for every application in the fill-finish workflow.

Certificates

Product Image-171-2709

Accessories for VWR® Water Purification System

Catalog Number: (171-2709)
Supplier: VWR Collection
Description: FLODEM single-use demineralisation cartridge, VWR®
UOM: 1 * 1 items
Image Unavailable-COMAPX33L

Immersion probe

Catalog Number: (COMAPX33L)
Supplier: COMARK
Description: The PX33L Integral Plug Probe is a general purpose penetration probe that connects directly to a thermometer for single-handed temperature taking.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-6125R-A750

Anti-p95 NBS1 Ser343 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-6125R-A750)
Supplier: Bioss
Description: Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability.
UOM: 1 * 100 µl
Product Image-663-0153

Conductivity cells, IDS

Supplier: WTW
Description: High quality, enhanced sensor technology combined with most up to date measurement electronics. For use with IDS meters.

Product Image-663-0356

VWR® pHenomenal® IDP 761-C Conductivity Cell

Catalog Number: (663-0356)
Supplier: VWR Collection
Description: This IDP (Intelligent Digital Probe) conductivity/temperature cell can be used with the pHenomenal® MD 8000 H and MD 8000 L multi-parameter meters.
UOM: 1 * 1 items
Image Unavailable-C5041-25MG

6-CFDA (6-Carboxyfluorescein diacetate, single isomer), Sigma-Aldrich®

Supplier: SIGMA ALDRICH MICROSCOPY
Description: Used to differentiate viable cells from apoptotic cells. Live cells that are not apoptotic accumulate 6-carboxyfluorescein but do not accumulate annexin. Fluorescent wavelengths λex 492 nm; λemm 517 nm in 0.1 M Tris, pH 8.0.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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