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Image Unavailable-BOSSBS-6124R-CY5

Anti-NBN Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-6124R-CY5)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-CY3

Anti-NBN Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-6124R-CY3)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-A488

Anti-NBN Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-6124R-A488)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-CONTMGMP0001

Single use microfibre products, MicroGenesis™

Catalog Number: (CONTMGMP0001)
Supplier: CONTEC
Description: These single use microfibre pads feature synthetic construction for the effective removal of both gross contamination and fine particles. Conveniently designed to provide a new pad for each new use, they are compatible with most existing hardware.
UOM: 1 * 140 items
Product Image-MFLX74000-59-EU

Masterflex® EtherNet/IP™ Compatible Drives Powering Quattroflow™ Pumps

Supplier: Avantor Fluid Handling
Description: Monitor transfer of delicate biological fluids with EtherNet/IP™ control capability.

CE Compliant CSA Certified 2 year warranty

Image Unavailable-BOSSBS-6124R-FITC

Anti-NBN Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-6124R-FITC)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-A750

Anti-p95 NBS1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-6124R-A750)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-VEPA3FSKS610506

Single Use Test Packs, Bowie and Dick Type

Catalog Number: (VEPA3FSKS610506)
Supplier: VP Medical Packaging
Description: Sterilisation indicator, Bowie-dick single use test pack (prime-pack)
UOM: 1 * 50 items

New Product


Image Unavailable-SH31140.02

Sodium chloride solution 1 M, in single-use containers, HyClone™ for bioprocessing

Supplier: HyClone products (Cytiva)
Description: HyClone™ NaCl solutions in single-use bags offer a convenient format for many upstream and downstream bioprocessing applications.

Product Image-SCTV108335-T

SymLine Automatic Switching for Container

Supplier: S.C.A.T.
Description: The ready-to-use automatic switching sets prevent the overflowing of disposal containers and the associated leakage of hazardous, toxic, or explosive liquid waste.

New Product

Product Image-521-3944

Rotors, Avanti JA 12

Supplier: Beckman Coulter
Description: JA 12 fixed angle (high performance) rotor with single locking lid for use in Avanti J Series and J2 Series centrifuges

Product Image-734-2966

VWR® Single-Well Cell Culture Plates

Supplier: VWR Collection
Description: Single-well cell culture plates, made from clear PS, are available plasma-treated for consistent cell attachment and growth, or non-treated for use in applications where cell attachment is not desired.

Certificates Environmentally Preferable

Image Unavailable-OXOIDD0011T

Antibiotic assay discs, differentiation discs (DD)

Supplier: THERMO FISHER DIAGNOSTICS
Description: Used as a screening test prior to serological grouping.

Certificates

Product Image-MILFPSMW010R5

Accessories for Millicell® Cell Culture Insert Plates, 24 Wells

Supplier: Merck
Description: Cell Culture Plate, Single-well feeder tray, lid, for use with 24-well cell culture plate only

Image Unavailable-H66517.03

Brooker's merocyanine indicator dyed

Supplier: Thermo Fisher Scientific
Description: Brooker's merocyanine dye is used as solvent polarity indicators. It is used as pH sensors and transition metal cation indicators.

Certificates

Product Image-CONTTASK0850

QuickTask™ Microfibre Mop Heads

Supplier: CONTEC
Description: Single-use, 100% polyester single-loop microfibre flat mop head.

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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