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Product Image-BOSSBS-1922R

Anti-TRF2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-1922R)
Supplier: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1922R-A680

Anti-TRF2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-1922R-A680)
Supplier: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Product Image-ELTN729391/35

ESD safety shoes, MADDOX, low, S3

Supplier: ELTEN
Description: Excellent wearing comfort, with a padded upper edge to protect the Achilles tendon.

Environmentally Preferable

Product Image-ELTN760511/48

ESD safety ankle boots, DIALUTION, Mid, S3

Supplier: ELTEN
Description: Excellent wearing comfort, with a padded upper edge to protect the Achilles tendon.

Environmentally Preferable

Product Image-114-8998

ESD safety shoes, PURE Slipper, Low, S2

Supplier: ELTEN
Description: Excellent wearing comfort, with a padded upper edge to protect the Achilles tendon.

Environmentally Preferable

Product Image-115-3057

Dual-wire fabric wristband, SCS

Supplier: DESCO
Description: The Dual-wire fabric wristband is available in one size that adjusts to almost any size wrist for reliable protection.

Image Unavailable-APOSOR6133-1G

(±)-3-(Boc-amino)piperidine 97%

Supplier: Apollo Scientific
Description: (±)-3-(Boc-amino)piperidine 97%

Product Image-111-2525

Safety spectacles, 3700 series, SecureFit™

Supplier: 3M
Description: SecureFit™ 3700 series are safety over-spectacles designed for use with prescription glasses. These lightweight over-spectacles are designed to fit over the users existing glasses to provide personalised protection.

Image Unavailable-APOSOR2566-1G

1-Boc-5-aminoindole 95%

Catalog Number: (APOSOR2566-1G)
Supplier: Apollo Scientific
Description: 1-Boc-5-aminoindole 95%
UOM: 1 * 1 g
Product Image-ANSE11-528/7

Industrial gloves, HyFlex® 11-528

Supplier: Ansell
Description: This glass-free INTERCEPT liner provides increased cut protection and lasting comfort and protection for hard-working hands.

Image Unavailable-APOSOR40087-100MG

1-Boc-3-(bromomethyl)piperidine

Catalog Number: (APOSOR40087-100MG)
Supplier: Apollo Scientific
Description: 1-Boc-3-(bromomethyl)piperidine
UOM: 1 * 100 mg
Image Unavailable-BOSSBS-1922R-CY5.5

Anti-TRF2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-1922R-CY5.5)
Supplier: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1922R-HRP

Anti-TRF2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-1922R-HRP)
Supplier: Bioss
Description: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2379R-A555

Anti-LAMP2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-2379R-A555)
Supplier: Bioss
Description: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
UOM: 1 * 100 µl
Product Image-MMMAS2024AS-RED

Safety spectacles, Solus™ 2000 series

Supplier: 3M
Description: Comfortable, stylish eyewear with a vast array of colour and lens tint options, the Solus™ 2000 series provides eye protection with a stylish flare.

Product Image-SCOT292807358

Bottle base protector, for 5 L bottles, DURAN®

Catalog Number: (SCOT292807358)
Supplier: DWK Life Sciences
Description: Protects the base of 5 L bottles from damage during transport around the laboratory or production facility.
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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