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Supplier: ENZO LIFE SCIENCES
Description: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Supplier: ENZO LIFE SCIENCES
Description: Multidrug resistance transporter activator.

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Catalog Number: (ENZOBMLG1450050)
Supplier: ENZO LIFE SCIENCES
Description: <i>Clostridium difficile</i> toxoid A from<i> Clostridium difficile</i>, strain VPI10463 is a high potency toxin applicable to ELISA, antibody capture, cytotoxicity studies, immunogen and LINE assay.
UOM: 1 * 50 µG

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Catalog Number: (ENZOBMLG1000050)
Supplier: ENZO LIFE SCIENCES
Description: Ultra-pure
UOM: 1 * 50 µG

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Supplier: ENZO LIFE SCIENCES
Description: Acetyl-CoA inhibitor

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Catalog Number: (ENZOBMLEI2940001)
Supplier: ENZO LIFE SCIENCES
Description: Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES
Description: Src kinase inhibitor

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Supplier: ENZO LIFE SCIENCES
Description: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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Catalog Number: (ENZOBMLEI3080001)
Supplier: ENZO LIFE SCIENCES
Description: HSP90 inhibitor
UOM: 1 * 1 mg

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Catalog Number: (ENZOBMLEI3100005)
Supplier: ENZO LIFE SCIENCES
Description: Inhibitor of CDK and GSK
UOM: 1 * 5 mg

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Catalog Number: (ENZOADI900022)
Supplier: ENZO LIFE SCIENCES
Description: The Big Endothelin-1 (Human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight +1 hour.
UOM: 1 * 1 KIT

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Catalog Number: (ENZOADI900050)
Supplier: ENZO LIFE SCIENCES
Description: Sensitive ELISA kit enabling detection of 12(S)-HETE in culture supernatants and plasma from any species.
UOM: 1 * 1 KIT

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Supplier: ENZO LIFE SCIENCES
Description: The Cortisol EIA kit is a colorimetric competitive enzyme immunoassay kit for the quantitative determination of cortisol in culture supernatants, plasma, serum, saliva, and urine from any species.

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Catalog Number: (ENZOADI900135)
Supplier: ENZO LIFE SCIENCES
Description: For the quantitative determination of β-Catenin in cell lysates of human, mouse, and rat origin.
UOM: 1 * 1 KIT

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Catalog Number: (ENZOBMLEI3510001)
Supplier: ENZO LIFE SCIENCES
Description: STAT inhibitor
UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES
Description: For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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