You Searched For: Phenylpropiolaldehyde+diethyl+acetal

Catalog Number: (PRSI79-616)

Supplier: ProSci Inc.

Description: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSIXG-6199)

Supplier: ProSci Inc.

Description: Anti-WRB Chicken Polyclonal Antibody

UOM: 1 * 500 µG

Sale

Catalog Number: (PRSI79-649)

Supplier: ProSci Inc.

Description: Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation. Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSI79-640)

Supplier: ProSci Inc.

Description: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSIXG-6180)

Supplier: ProSci Inc.

Description: Anti-MAP2K1 Chicken Polyclonal Antibody

UOM: 1 * 50 µl

Sale

Catalog Number: (PRSIXPS-1011)

Supplier: ProSci Inc.

Description: GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration. There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone. GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser41 by Protein Kinase C modulates the interaction of GAP-43 with actin.

UOM: 1 * 100 µl

Sale

Catalog Number: (PRSIXG-6181)

Supplier: ProSci Inc.

Description: Anti-MAPK14 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

Sale

Catalog Number: (PRSIXPS-1000)

Supplier: ProSci Inc.

Description: Calcium/calmodulin kinase II (CaM Kinase II) is multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to second messengers. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. The antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr286 found in rat brain CaM Kinase II.

UOM: 1 * 100 µl

Sale

Catalog Number: (PRSIXG-6176)

Supplier: ProSci Inc.

Description: Anti-CRP Chicken Polyclonal Antibody

UOM: 1 * 100 µl

Sale

Catalog Number: (PRSI79-575)

Supplier: ProSci Inc.

Description: Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSI79-576)

Supplier: ProSci Inc.

Description: Ephrin-B2 encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a lycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSI79-591)

Supplier: ProSci Inc.

Description: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSIXG-6121)

Supplier: ProSci Inc.

Description: Anti-ETS2 Chicken Polyclonal Antibody

UOM: 1 * 500 µG

Sale

Catalog Number: (PRSI79-724)

Supplier: ProSci Inc.

Description: The CD3 complex mediates signal transduction.

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSI79-716)

Supplier: ProSci Inc.

Description: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1, 4-glucan.

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSIXW-7061)

Supplier: ProSci Inc.

Description: Human complement component C3. Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the beta chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement-pathway C3/C5 convertase.C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.

UOM: 1 * 50 µG

Sale