You Searched For: ProSci Inc.

Catalog Number: (PRSI79-467)

Supplier: ProSci Inc.

Description: APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-477)

Supplier: ProSci Inc.

Description: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-478)

Supplier: ProSci Inc.

Description: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

UOM: 1 * 100 µG

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Catalog Number: (PRSI70-528)

Supplier: ProSci Inc.

Description: Anti-MUC16 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI79-498)

Supplier: ProSci Inc.

Description: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-493)

Supplier: ProSci Inc.

Description: The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-494)

Supplier: ProSci Inc.

Description: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-513)

Supplier: ProSci Inc.

Description: SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)

UOM: 1 * 100 µG

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Catalog Number: (PRSI71-180)

Supplier: ProSci Inc.

Description: Anti-ENTPD2 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Catalog Number: (PRSI51-350)

Supplier: ProSci Inc.

Description: Anti-FCER1A Mouse Monoclonal Antibody

UOM: 1 * 50 µG

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Catalog Number: (PRSIXA-1014)

Supplier: ProSci Inc.

Description: Anti-TNFSF13 Rat Monoclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSIXA-1022)

Supplier: ProSci Inc.

Description: Anti-TOLLIP Mouse Monoclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSIXPS-2005)

Supplier: ProSci Inc.

Description: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.

UOM: 1 * 100 µl

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Catalog Number: (PRSIXPS-2026)

Supplier: ProSci Inc.

Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

UOM: 1 * 10 µG

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Catalog Number: (PRSI79-662)

Supplier: ProSci Inc.

Description: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-654)

Supplier: ProSci Inc.

Description: Cyclin-dependent kinase activity is regulated by T-loop phosphorylation (Thr172 in the case of CDK4), by the abundance of their cyclin partners, and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of CDK4/cyclin D and p27 Kip1/Cip1 requires extracellular mitogenic stimuli for the release and degradation of p27, which affects progression through the restriction point and pRb-dependent entry into S-phase. The active complex of CDK4/cyclin D targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. In HeLa cells, upon UV irradiation, upregulation of p16 INK4A association with CDK4/cyclin D3 leads to a G2 delay, implicating CDK4/cyclin D3 activity in progression through the G2-phase of the cell cycle.

UOM: 1 * 100 µG

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