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Catalog Number: (PRSI33-700)

Supplier: ProSci Inc.

Description: This antibody recognises a carbohydrate epitope present on tumor-associated Lewis Y antigen (Fucalpha1-2Galbeta1-4/3[Fucalpha1-3/4]GlcNAcbeta-). Lewis Y is expressed in large bowel tumors and colorectal carcinomas. It may be useful in the classification of human renal and bladder tumors. The Lewis Y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-708)

Supplier: ProSci Inc.

Description: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-754)

Supplier: ProSci Inc.

Description: Recognises a protein of about 50 kDa, which is identified as gamma-Enolase/Neuron Specific Enolase/Enolase 2. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue and gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-727)

Supplier: ProSci Inc.

Description: Villin (VIL1) is an epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. [UniProt].

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-734)

Supplier: ProSci Inc.

Description: It recognises a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases 2 (TIMP2). It is closely related to TIMP1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP9 or gelatinase B). TIMP2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-752)

Supplier: ProSci Inc.

Description: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin alpha and spectrin beta are present in erythrocytes, whereas spectrin alphaII (fodrin alpha) and spectrin betaI (fodrin beta) are present in other somatic cells. SPTBN2/Spectrin betaIII is highly homologous to both spectrin betaI and spectrin betaII. SPTBN2 is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-753)

Supplier: ProSci Inc.

Description: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin alpha and spectrin beta are present in erythrocytes, whereas spectrin alphaII (fodrin alpha) and spectrin betaI (fodrin beta) are present in other somatic cells. SPTBN2/Spectrin betaIII is highly homologous to both spectrin betaI and spectrin betaII. SPTBN2 is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta.

UOM: 1 * 100 µG

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Catalog Number: (PRSI59-417)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI59-408)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI59-423)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI59-649)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI76-394)

Supplier: ProSci Inc.

Description: The 61D3 monoclonal antibody specifically reacts with CD14, a cell surface anchored glycoprotein that is primarily expressed on monocytes, inerfollicular macrophages, and a subset of dendritic cells. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB.

UOM: 1 * 25 Tests

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Catalog Number: (PRSI59-650)

Supplier: ProSci Inc.

Description: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI61-056)

Supplier: ProSci Inc.

Description: For FACS starting dilution is: 1:25. For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI61-057)

Supplier: ProSci Inc.

Description: For IHC-P starting dilution is: 1:25. For FACS starting dilution is: 1:25. For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

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Catalog Number: (PRSI56-151)

Supplier: ProSci Inc.

Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

UOM: 1 * 400 µl

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