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N-Arachidonoyl-L-Serine 1% in ethanol , 98%

Catalog Number: (CAYM10005455-10)

Supplier: Cayman Chemical

Description: Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.
(1)N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model.
(2)However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.
(3)The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.

UOM: 1 * 10 mg

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Anti-Neuropeptide Y Receptor Type 1 Rabbit Polyclonal Antibody

Catalog Number: (ENZOADI905798100)

Supplier: ENZO LIFE SCIENCES

Description: Neuropeptide Y (NPY) and the closely related peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino acid, tyrosine-rich peptides with amidated C-terminal ends that are known to regulate gastrointestinal and central nervous system functions including food intake and the inhibition of anxiety. Four functional NPY receptors (Y1/Y2/Y4/Y5) have been identified to date, with a fifth (y6) being a non-functional receptor in primates that is absent from the rat genome. Y1, Y2, and Y5 receptors preferentially bind NPY and PYY, while the Y4 receptor preferentially binds PP. All four receptors signal via coupling to Gi/o alpha subunits, inhibiting adenylyl cyclase activity, thereby decreasing intracellular cAMP levels. Y1 receptor deficient mice display a variety of physical and behavioral phenotypes including obesity, hyperinsulinemia, and increased territorial behavior.

UOM: 1 * 100 µG

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4-(Morpholino)phenylboronic acid pinacol ester

Supplier: Thermo Scientific

Description: 4-(Morpholino)phenylboronic acid pinacol ester

Marfey's reagent (FDAA or 1-fluoro-2-4-dinitrophenyl-5-L-alanine amide), Pierce™

Catalog Number: (PIER48895)

Supplier: Thermo Fisher Scientific

Description: Marfey's Reagent (FDAA or 1-fluoro-2-4-dinitrophenyl-5-L-alanine amide) reacts with primary amines to enable the quick and easy separation and quantitation of optical isomers of amino acids by reverse-phase chromatography.

UOM: 1 * 50 mg

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