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Product Image-111-2171

Escape hoods, Parat® 7500

Catalog Number: (111-2171)
Supplier: Dräger
Description: This combined fire and industrial escape hood was developed with users, placing the focus on the fastest possible escape. Optimised operation and wearing comfort, a robust housing and a tested ABEK CO P3 filter ensure protection from toxic industrial and fire-related gases, vapours and particles for at least 15 minutes.
UOM: 1 * 1 items
Product Image-SCTS1046044

Accessories for self contained breathing apparatus, Cen-Paq

Supplier: SCOTT SAFETY
Description: Steel cylinder, valve fitted with safety locking handwheel, 3,0 litre, 200 bar for total duration of 15 minutes, 5 kg, ∅ 110 mm x length: 375 mm, fully charged, for short duration breathing apparatus Cen-Paq, Cen-Paq

Product Image-RPBS03-895-ABEK

Respirators, gas filters, PX5 PAPR Series

Supplier: RPB SAFETY
Description: The RPB PX5 is a battery powered air purifying respirator fan unit which draws in contaminated air from the wearer's immediate vicinity, passing it through internal filters, and supplying the filtered air to an approved RPB loose fitting respirator head top.

Product Image-111-2170

Escape hoods, Parat® 4700

Catalog Number: (111-2170)
Supplier: Dräger
Description: This combined fire and industrial escape hood was developed with users, placing the focus on the fastest possible escape. Optimised operation and wearing comfort, a robust housing and a tested ABEK P3 filter ensure protection from toxic industrial gases, vapours and particles for at least 15 minutes.
UOM: 1 * 1 items
Product Image-DALL1013980

Powered air purifying respirators (PAPR), Airvisor 2

Supplier: HONEYWELL SAFETY
Description: Airvisor 2 MV Chemical Kit with acetate chemical resistant visor, two disposable visor covers, fabric hood and neck cover, waist belt complete, carry bag. For applications exposed to chemicals.
Airvisor 2 MV Industry Kit with polycarbonate impact resistant visor, one fabric cassette, two disposable visor covers and head cover, waist belt complete, carrying bag. For industrial applications.

Product Image-RPBS17-120-12

SAR Respirators headtop and SAR breathing tubes, T-Link Series

Catalog Number: (RPBS17-120-12)
Supplier: RPB SAFETY
Description: The RPB T-Link respirator is a lightweight, multi-purpose TH3 respirator designed specifically for a range of industries, including healthcare, pharmaceutical, and industrial painting and coating. The advanced cradle provides unmatched comfort for the wearer, and keeps the lens and hood mounted solidly.
UOM:


Product Image-RPBS17-110-12-CE

Respirators TH3 headtop and PX5 PAPR breathing tubes, T-Link Series

Catalog Number: (RPBS17-110-12-CE)
Supplier: RPB SAFETY
Description: The RPB T-Link respirator is a lightweight, multi-purpose TH3 respirator designed specifically for a range of industries, including healthcare, pharmaceutical, and industrial painting and coating. The advanced cradle provides unmatched comfort for the wearer, and keeps the lens and hood mounted solidly.
UOM: 1 * 1 items
Product Image-PRSI6455

Anti-DBX1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI6455)
Supplier: ProSci Inc.
Description: DBX1 Antibody: DBX1 is implicated in patterning the central nervous system during embryogenesis. DBX1 homeodomain transcription factor is expressed in progenitors which are critical in establishing cell fate allocation and cell diversity. DBX1 has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. DBX1-derived neurons are essential for the transgenic expression and generation of respiratory behavior both in vitro and in vivo.
UOM: 1 * 100 µG
Product Image-PRSI6847

Anti-SDHD Rabbit Polyclonal Antibody

Catalog Number: (PRSI6847)
Supplier: ProSci Inc.
Description: SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
UOM: 1 * 100 µG
Image Unavailable-PRSI34-052

Anti-IGHG4 Mouse Monoclonal Antibody [clone: IHCG4-1]

Catalog Number: (PRSI34-052)
Supplier: ProSci Inc.
Description: The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterised by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
UOM: 1 * 100 µG

New Product


Image Unavailable-PRSI33-799

Anti-IGHG4 Mouse Monoclonal Antibody [clone: IGHG4/1345]

Catalog Number: (PRSI33-799)
Supplier: ProSci Inc.
Description: The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterised by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
UOM: 1 * 100 µG

New Product


Product Image-PRSI96-400

Human recombinant ICAM1 (from HEK293 cells)

Catalog Number: (PRSI96-400)
Supplier: ProSci Inc.
Description: Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.
UOM: 1 * 200 µG
Image Unavailable-PRSI92-266

Human recombinant IL22 (from E. coli)

Catalog Number: (PRSI92-266)
Supplier: ProSci Inc.
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
UOM: 1 * 50 µG
Image Unavailable-PRSI92-662

Human recombinant IL22 (from cells)

Catalog Number: (PRSI92-662)
Supplier: ProSci Inc.
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
UOM: 1 * 50 µG
Image Unavailable-PRSI92-661

Human recombinant IL22 (from cells)

Catalog Number: (PRSI92-661)
Supplier: ProSci Inc.
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.
UOM: 1 * 50 µG
Product Image-PRSI25-944

Anti-CYBB Rabbit Polyclonal Antibody

Catalog Number: (PRSI25-944)
Supplier: ProSci Inc.
Description: CYBB is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H (+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD).Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM: 1 * 50 µG
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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