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Catalog Number: (PRSI50-114)

Supplier: ProSci Inc.

Description: Anti-GRIN2C Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalog Number: (PRSI46-741)

Supplier: ProSci Inc.

Description: Anti-LIPG Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI50-183)

Supplier: ProSci Inc.

Description: NSF (N-ethylmaleimide sensitive fusion protein) is a critical component of the SNARE (soluble NSF attachment protein receptors) protein complex that is involved in synaptic vesicle trafficking. Specifically, NSF has been found to be essential in membrane fusion. Furthermore, NSF has been recently demonstrated to bind other protein complexes such as AMPA receptor subunits (GluR2), GATE-16, LMA-1 and Rabs suggesting a more diverse role in the assembly of various protein complexes (Whiteheart et al., 2004).

UOM: 1 * 100 µl

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Catalog Number: (PRSI50-177)

Supplier: ProSci Inc.

Description: Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

UOM: 1 * 100 µl

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Catalog Number: (PRSI49-331)

Supplier: ProSci Inc.

Description: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.

UOM: 1 * 50 µG

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Catalog Number: (PRSI46-780)

Supplier: ProSci Inc.

Description: Anti-TAS1R3 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI46-785)

Supplier: ProSci Inc.

Description: Anti-ANXA1 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI46-765)

Supplier: ProSci Inc.

Description: Anti-ORAI1 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI50-228)

Supplier: ProSci Inc.

Description: Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that is involved in the regulation of many signaling pathways. To date, 2 isoforms have been identified: GSK3alpha and GSK3beta. Specifically, GSK3beta has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways (Papkoff and Aikawa 1998). It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3beta by insulin (Sutherland et al., 1993).

UOM: 1 * 100 µl

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Catalog Number: (PRSI50-220)

Supplier: ProSci Inc.

Description: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin 43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin 43 that results in a decrease in gap junction permeability (Bao et al., 2004b).

UOM: 1 * 100 µl

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Catalog Number: (PRSI46-757)

Supplier: ProSci Inc.

Description: Anti-SEPT7 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI46-777)

Supplier: ProSci Inc.

Description: Anti-DES Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI46-793)

Supplier: ProSci Inc.

Description: Anti-ABCB8 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI46-813)

Supplier: ProSci Inc.

Description: Anti-ASNA1 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI50-266)

Supplier: ProSci Inc.

Description: Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5 kDa), is essential for yeast viability, and is localized in the nucleoli. The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34 kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6).

UOM: 1 * 100 µl

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Catalog Number: (PRSI79-399)

Supplier: ProSci Inc.

Description: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

UOM: 1 * 100 µG

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