You Searched For: ProSci Inc.

Catalog Number: (PRSI79-121)

Supplier: ProSci Inc.

Description: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-140)

Supplier: ProSci Inc.

Description: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-127)

Supplier: ProSci Inc.

Description: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-135)

Supplier: ProSci Inc.

Description: The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-154)

Supplier: ProSci Inc.

Description: Transcription factor.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-150)

Supplier: ProSci Inc.

Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-153)

Supplier: ProSci Inc.

Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-172)

Supplier: ProSci Inc.

Description: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-166)

Supplier: ProSci Inc.

Description: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-175)

Supplier: ProSci Inc.

Description: Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

UOM: 1 * 100 µG

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Catalog Number: (PRSI79-161)

Supplier: ProSci Inc.

Description: Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ-B-regulated promoters during inflammatory responses triggered by cytokines.

UOM: 1 * 100 µG

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Catalog Number: (PRSI70-832)

Supplier: ProSci Inc.

Description: Anti-SLC5A3 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI46-861)

Supplier: ProSci Inc.

Description: Anti-LPO Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI48-641)

Supplier: ProSci Inc.

Description: Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). Akt1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for it activity.

UOM: 1 * 50 µG

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Catalog Number: (PRSI51-267)

Supplier: ProSci Inc.

Description: Anti-CXCR2 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

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Catalog Number: (PRSI46-879)

Supplier: ProSci Inc.

Description: Anti-NOTCH1B Goat Polyclonal Antibody

UOM: 1 * 100 µG

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