You Searched For: ProSci Inc.

Catalog Number: (PRSI20-256)

Supplier: ProSci Inc.

Description: Anti-ORF1ab Sheep Polyclonal Antibody

UOM: 1 * 0,1 mg

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Catalog Number: (PRSI20-270)

Supplier: ProSci Inc.

Description: Anti-N Sheep Polyclonal Antibody

UOM: 1 * 0,1 mg

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Catalog Number: (PRSI19-976)

Supplier: ProSci Inc.

Description: Anti-AQR Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI19-965)

Supplier: ProSci Inc.

Description: Anti-ZCCHC11 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI19-982)

Supplier: ProSci Inc.

Description: Anti-HDLBP Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI19-985)

Supplier: ProSci Inc.

Description: Anti-PAIP1 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

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Catalog Number: (PRSI33-104)

Supplier: ProSci Inc.

Description: A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B-cell Ag receptor. CD79a first appears at pre B-cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. It is found in the majority of acute leukemias of B-cell precursors, lines and lymphomas, and in some myelomas. It is not present in myeloid or Tcell lines. CD79a antibody is generally used to complement CD20 mAb, especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This CD79a antibody will stain many of the same lymphomas as CD20 mAb, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is CD20 mAb. CD79a antibody also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-052)

Supplier: ProSci Inc.

Description: CYLD is involved in multiple physiological processes including immune response, osteoclastogenesis and spermatogenesis. It is a tumor suppressor via its negative regulation of NF-kB activation. CYLD is a deubiquitinase, removing ubiquitin chains from tumor-necrosis factor receptor-associated factor 2 (TRAF2) and thereby preventing its activation of IkB, a regulator of NF-kB. NF-kB remains sequestered in the cytoplasm, unable to translocate to the nucleus and initiate cell survival and oncogenetic signaling.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-063)

Supplier: ProSci Inc.

Description: Autophagy is the cellular mechanism of degradation and turnover of unnecessary or dysfunctional cellular components. The unneeded components are engulfed in vesicles called autophagosomes, where they are broken down and recycled. The ‘autophagy-related gene’ ATG4B is a regulator of autophagasome maturation. The microtubule-associated protein LC3-I is lipidated (called LC3-II in its lipidated state) and recruited to the autophagosomal membrane where it is of vital importance in the maturation of autophagosomes. ATG4B regulates LC3-II availability by modulating LC3-I lipidation.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-081)

Supplier: ProSci Inc.

Description: CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimises immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-051)

Supplier: ProSci Inc.

Description: HMGB1 is a promoter of the immune response to injury or infection. It is released from dying cells (necrotic, not apoptotic), activating the immune system in anticipation of infection and encouraging tissue repair by attracting and promoting the proliferation of stem cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-080)

Supplier: ProSci Inc.

Description: CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific Tcell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimises immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-060)

Supplier: ProSci Inc.

Description: DEAD box proteins are RNA helicases involved in cellular processes involving the alteration of RNA secondary structure. DDX4, DEAD box polypeptide 4, is the mammalian homolog of the Drosophila VASA gene. DDX4 is expressed solely in ovarian and testicular germ cells and therefore a useful germ cell lineage marker and possible useful biomarker for germ cell cancers.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-089)

Supplier: ProSci Inc.

Description: This antibody recognises a protein of 33-37 kDa, identified as CD20 (Workshop V; Code CD20.12). The antibody recognises the extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, Bcell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of Bcells and its expression is restricted to normal and neoplastic Bcells, being absent from all other leukocytes and tissues. It is expressed by pre Bcells and persists during all stages of Bcell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting Bcells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in Bcell activation and cell cycle progression.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-097)

Supplier: ProSci Inc.

Description: This antibody recognises a single chain, transmembrane, heavily glycosylated protein of 90 to 120 kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but shows low specificity.

UOM: 1 * 100 µG

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Catalog Number: (PRSI33-094)

Supplier: ProSci Inc.

Description: The antibody recognises a single chain glycoprotein of 105/120 kDa, identified as CD30/Ki-1. CD30 is synthesised as a 90 kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120 kDa glycoprotein. In Hodgkin’s disease, CD30 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This antibody distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the CD30 positive lymphomas lack the leukocyte common antigen (CD45).

UOM: 1 * 100 µG

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