You Searched For: Radiation+Shields

Catalog Number: (DALL820444)

Supplier: HONEYWELL SAFETY

Description: Faceshield for all industrial applications. Browguard made from clear acetate, visor from non-mist treated acetate and carrier from polyamide. Protects against impacts from flying particles of low energy, hot solid penetration, splashes of liquids and liquid sprays and is resistant to numerous solvents, acids and alkalis.

UOM: 1 * 1 items

Sale

Supplier: EDWARDS HIGH VACUUM METTLER

Description: The XDS pumps are used as a patented bearing shield to isolate the vacuum environment from all forms of lubricant, not only making it totally dry, but hermetically sealed. The shield also protects the bearing from any process vapours. Adjustable gas ballast allows vapour to be handled and opens up the range of applications to many that were previously unsuited to scroll pumps. The XDS-C range are designed for pumping condensable vapors and use materials selected for a wide range of laboratory wet chemistry applications.

Supplier: JUSTRITE MANUFACTURING

Description: These waterproof traps are used to protect drums and equipment to avoid contamination or damage and also shield equipment from harsh effects of direct sunlight, sand, dust and rain.

Catalog Number: (BINH1013885)

Supplier: 3B Scientific

Description: Highly evacuated electron tube for determining the wavelength of electrons as a function of the anode voltage from the radii of the diffraction rings and the distance between the lattice planes of graphite (Debye-Scherrer-diffraction) and rendered visible on a fluorescent screen. Also intended for determining the wavelengths of monochromatic radiation at different anode voltages from the radii of the diffraction rings and the lattice plane spacing of graphite, as well as confirming de Broglie’s hypothesis.

UOM: 1 * 1 items

Sale

Catalog Number: (PRSI91-954)

Supplier: ProSci Inc.

Description: RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize beta catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/ beta catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.

UOM: 1 * 50 µG

Sale

Catalog Number: (BOSSBS-0501R-FITC)

Supplier: Bioss

Description: JNK1(MAPK8) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity. The cell-permeable JNK inhibitory peptide may have promise as a therapeutic agent for diabetes.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-4000R)

Supplier: Bioss

Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-5257R)

Supplier: Bioss

Description: Chk2 is a serine/threonine kinase involved in the control of cell cycle checkpoints, and may also participate in transduction of the DNA damage and replicational stress signals. Chk2 is the mammalian ortholog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine and threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be preferred sites for phosphorylation by ATM/ATR kinases. Indeed, after DNA damage by ionizing radiation (IR), UV irradiation or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Phosphorylation at Thr68 is a prerequisite for the subsequent activation step, which is attributable to autophosphorylation of Chk2 on residues Thr383 and Thr387 in the activation loop of the kinase domain. Chk2 inhibits CDC25C phosphatase by phosphorylating it on Ser-216, preventing the entry into mitosis. This kinase may have a role in meiosis as well. Kinase activity is up regulated by autophosphorylation and the protein is rapidly phosphorylated in response to DNA damage and to replication block.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-0518R-CY5.5)

Supplier: Bioss

Description: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

UOM: 1 * 100 µl

Sale

Catalog Number: (BOSSBS-0518R-A555)

Supplier: Bioss

Description: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

UOM: 1 * 100 µl

Sale

Supplier: S▄DPACK MEDICA

Description: The discs are available in a variety of blank or printed versions.

Certificates

Supplier: NEW PIG

Description: These lightweight gloves made of Norfoil® laminate provide lightweight protection from corrosive chemicals. They resist permeation and breakthrough of even the most dangerous liquids like aromatics, ketones, alcohols, esters and chlorinated and aliphatic solvents.

Catalog Number: (IDCPMSAH352)

Supplier: Dino-Lite / IDCP B.V.

Description: Accessory for handheld microscope, Silicone protection cover, MSAH352, shields the microscope from dirt and stains, compatible with all Dino-Lite models

UOM: 1 * 1 items

Sale

Catalog Number: (PRSI79-387)

Supplier: ProSci Inc.

Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation

UOM: 1 * 100 µG

Sale

Catalog Number: (PRSI3341)

Supplier: ProSci Inc.

Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

UOM: 1 * 100 µG

Sale

Catalog Number: (765-1092)

Supplier: MOLLER THERM

Description: Radiometer according to Crookés. Consists of a glass container on foot with low air pressure and needle-bearing spinner with four vertical mica discs. The discs are black on one side and shiny on the other. The discs thus absorb radiation differently. The higher temperature of the dark side means that the air molecules get greater kinetic energy in collision with the dark side of the discs than with their shiny side. The result is that the spinner starts to rotate.

UOM: 1 * 1 items

Sale