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Catalog Number: (BOSSBS-11041R-CY5)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
UOM: 1 * 100 µl


Supplier: Thermo Fisher Scientific
Description: <p>The Thermo Scientific™ IntelliStack™ accessories are designed to work with the IntelliStack Incubator Shaker and IntelliStack CO₂ Incubator Shaker.</p>

New Product

Catalog Number: (BOSSBS-11041R-FITC)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11041R-A555)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
UOM: 1 * 100 µl


Supplier: VWR Collection
Description: Tube rollers are designed for the gentle, thorough mixing of a variety of containers, including Vacutainers™, bottles, test tubes, centrifuge tubes and roller bottles.

Catalog Number: (444-1343)
Supplier: VWR Collection
Description: The VWR® rotating mixer provides gentle to vigorous mixing of samples in up to 50 ml tubes.
UOM: 1 * 1 items


Supplier: VWR Collection
Description: Digital shakers with microprocessor control which are ideal for mixing applications with very heavy loads and larger vessels, e.g. cell cultures, solubility studies and extraction procedures. Variable speed control provides consistent, uniform shaking action. The Accu-drive shaking system delivers exceptional speed control, accuracy, safety and durability, the system continuously monitors shaking speed and will maintain the set point even under changing loads.

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Catalog Number: (BOSSBS-11041R-A488)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
UOM: 1 * 100 µl


Catalog Number: (BARNSHKE416HP-1CE)
Supplier: Thermo Fisher Scientific
Description: MaxQ™ HP benchtop orbital shaker suitable for environmental rooms or on lab benches. It features balancing technology and rugged mechanism make smooth high-capacity 24/7 shaking a reality, an industry-leading platform size, wide-range speed, low heat output motor and spill-resistant design. It features set point security which restricts unauthorised or inadvertent changes to key functions. Equipped with alarm to know the shaker performance.
UOM: 1 * 1 items


Catalog Number: (PRSI55-785)
Supplier: ProSci Inc.
Description: The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.
UOM: 1 * 400 µl

New Product


Catalog Number: (444-0148)
Supplier: VWR Collection
Description: The mini nutating mixer that combines the action of an orbital shaker and a rocker to produce a three-dimensional motion which provides gentle yet thorough mixing without foaming. Ideal for mixing samples in blood and centrifuge tubes. Speed and angle of tilt are fixed, providing the optimum conditions for mixing and re-suspending samples in blood and centrifuge tubes.
UOM: 1 * 1 items


Catalog Number: (444-1115)
Supplier: Heidolph Instruments GmbH & Co.KG
Description: Platform shaker with three dimensional gyratory motion, designed for homogeneous mixing, ideal for distribution of cells or solutes, preparing slides and electrophoresis gels, culture plates and Erlenmeyer flasks. Polymax 2040 is suitable for large vessels and culture plates. Units have analogue dial controls for adjusting wave frequency and time.
UOM: 1 * 1 items


Supplier: VWR Collection
Description: Shaker, Shaking Incubator, VWR®

Catalog Number: (SCIISI-4110)
Supplier: SCIENTIFIC INDUSTRIES ELMIS
Description: Stacking tray for MultiPlate Genie
UOM: 1 * 1 items


Supplier: VWR Collection
Description: Tube holder kit (444-7047) consists of:

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Catalog Number: (444-0270)
Supplier: VWR Collection
Description: Microplate shaker with microprocessor control which holds two or four microplates, deep well plates or two microtube racks. Variable speed across a wide range may be adjusted to suit the application; a low speed ensures that the well contents are not ejected, more vigorous agitation provides effective aeration across the small surface area of each of the wells. Ideal for use in immunology, biotechnology, microbiology and pharmacology applications.
UOM: 1 * 1 items

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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