You Searched For: STEMCELL Technologies

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD4, PE-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b, kappa isotype control antibody, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse, toad CD8a, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter and Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright <i>et al.</i>). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds and Weiss).

Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220).

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b, biotin-conjugated.

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD45, unconjugated.

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi <i>et al.</i>). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause <i>et al.</i>), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba <i>et al.</i>).

Supplier: STEMCELL Technologies

Description: Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. After LIF binds to the LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling (Auernhammer and Melmed; Suman <i>et al.</i>). LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype (Niwa <i>et al.</i>). Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment (Auernhammer and Melmed; Suman <i>et al.</i>). Human LIF can be used for the maintenance of mouse embryonic stem cells; however, mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive (Dahéron <i>et al.</i>). LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes (Metcalfe). LIF is also secreted by mesenchymal stromal cells, where it supports hematopoiesis and immune modulation (Nasef <i>et al.</i>).

Catalog Number: (STMC60084)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rat CD36, unconjugated.

UOM: 1 * 0,1 mL

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Catalog Number: (STMC60032BT)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse Sca1 (Ly-6A/E), biotin-conjugated.

UOM: 1 * 500 µG

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Catalog Number: (STMC60132)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against rhesus red blood cells, unconjugated.

UOM: 1 * 0,1 mL

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Catalog Number: (STMC60147)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human epithelial cells, unconjugated.

UOM: 1 * 0,1 mL

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